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TargetTankyrase-2
LigandBDBM50007583
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1338771
IC50 56±n/a nM
Citation Liscio PCarotti AAsciutti SKarlberg TBellocchi DLlacuna LMacchiarulo AAaronson SASchüler HPellicciari RCamaioni E Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors. J Med Chem 57:2807-12 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Tankyrase-2
Name:Tankyrase-2
Synonyms:ADP-ribosyltransferase diphtheria toxin-like 6 | ARTD6 | TANK2 | TNKS-2 | TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | Tank2 | Tankyrase II | Tnks2
Type:PROTEIN
Mol. Mass.:126762.23
Organism:Mus musculus
Description:ChEMBL_108291
Residue:1166
Sequence:
MSGRRCAGGGAACASAGAEAVEPSARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKST
PLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLQHGADPNAR
DNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGDYKKDE
LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLHHGADVHAK
DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRIEVCSLLLSYG
ADPTLLNCHNKSAIDLAPTAQLKERLSYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH
PQTHETALHCAAASPYPKRKQICELLLRKGANTNEKTKEFLTPLHVASENAHNDVVEVVV
KHEAKVNALDSLGQTSLHRAAHCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQL
LQEGASLGHSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVS
VVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA
AKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLAR
VKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAA
SYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQT
PLDLVSADDVSALLTAAMPPSALPTCYKPQVLSGVRGPGATADALSSGPSSPSSLSAASS
LDNLSGSFSELSAVVSSSAAEGATGLQRKEDSGIDFSITQFIRNLGLEHLMDIFEREQIT
LDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNNSGSGTILIDLSP
DDKEFQSVEEEMQSTVREHRDGGHAGGVFNRYNILKIQKVCNKKLWERYTHRRKEVSEEN
HNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTG
CPIHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYV
IYRGEQAYPEYLITYQIVRPEGMVDG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50007583
n/a
NameBDBM50007583
Synonyms:CHEBI:62882 | CHEMBL562310
TypeSmall organic molecule
Emp. Form.C25H19N3O3
Mol. Mass.409.4367
SMILES[H][C@]12C[C@]([H])(C=C1)[C@]1([H])C(=O)N(C(=O)[C@]21[H])c1ccc(cc1)C(=O)Nc1cccc2cccnc12 |r,c:5|
Structure
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