| Reaction Details |
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 | Report a problem with these data |
| Target | Poly [ADP-ribose] polymerase tankyrase-2 |
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| Ligand | BDBM50007583 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1338771 (CHEMBL3242394) |
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| IC50 | 56±n/a nM |
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| Citation |  Liscio, P; Carotti, A; Asciutti, S; Karlberg, T; Bellocchi, D; Llacuna, L; Macchiarulo, A; Aaronson, SA; Schüler, H; Pellicciari, R; Camaioni, E Design, synthesis, crystallographic studies, and preliminary biological appraisal of new substituted triazolo[4,3-b]pyridazin-8-amine derivatives as tankyrase inhibitors. J Med Chem57:2807-12 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Poly [ADP-ribose] polymerase tankyrase-2 |
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| Name: | Poly [ADP-ribose] polymerase tankyrase-2 |
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| Synonyms: | ADP-ribosyltransferase diphtheria toxin-like 6 | ARTD6 | TNKS-2 | TNKS2_MOUSE | TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | Tank2 | Tankyrase II | Tankyrase-2 | Tnks2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 126762.23 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_108291 |
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| Residue: | 1166 |
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| Sequence: | MSGRRCAGGGAACASAGAEAVEPSARELFEACRNGDVERVKRLVTPEKVNSRDTAGRKST
PLHFAAGFGRKDVVEYLLQNGANVQARDDGGLIPLHNACSFGHAEVVNLLLQHGADPNAR
DNWNYTPLHEAAIKGKIDVCIVLLQHGAEPTIRNTDGRTALDLADPSAKAVLTGDYKKDE
LLESARSGNEEKMMALLTPLNVNCHASDGRKSTPLHLAAGYNRVKIVQLLLHHGADVHAK
DKGDLVPLHNACSYGHYEVTELLVKHGACVNAMDLWQFTPLHEAASKNRIEVCSLLLSYG
ADPTLLNCHNKSAIDLAPTAQLKERLSYEFKGHSLLQAAREADVTRIKKHLSLEMVNFKH
PQTHETALHCAAASPYPKRKQICELLLRKGANTNEKTKEFLTPLHVASENAHNDVVEVVV
KHEAKVNALDSLGQTSLHRAAHCGHLQTCRLLLSYGCDPNIISLQGFTALQMGNENVQQL
LQEGASLGHSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGYNRVS
VVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVNVADLWKFTPLHEAA
AKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGDTDIQDLLRGDAALLDAAKKGCLAR
VKKLSSPDNVNCRDTQGRHSTPLHLAAGYNNLEVAEYLLQHGADVNAQDKGGLIPLHNAA
SYGHVDVAALLIKYNACVNATDKWAFTPLHEAAQKGRTQLCALLLAHGADPTLKNQEGQT
PLDLVSADDVSALLTAAMPPSALPTCYKPQVLSGVRGPGATADALSSGPSSPSSLSAASS
LDNLSGSFSELSAVVSSSAAEGATGLQRKEDSGIDFSITQFIRNLGLEHLMDIFEREQIT
LDVLVEMGHKELKEIGINAYGHRHKLIKGVERLISGQQGLNPYLTLNNSGSGTILIDLSP
DDKEFQSVEEEMQSTVREHRDGGHAGGVFNRYNILKIQKVCNKKLWERYTHRRKEVSEEN
HNHANERMLFHGSPFVNAIIHKGFDERHAYIGGMFGAGIYFAENSSKSNQYVYGIGGGTG
CPIHKDRSCYICHRQLLFCRVTLGKSFLQFSAMKMAHSPPGHHSVTGRPSVNGLALAEYV
IYRGEQAYPEYLITYQIVRPEGMVDG
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| BDBM50007583 |
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| n/a |
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| Name | BDBM50007583 |
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| Synonyms: | CHEBI:62882 | CHEMBL562310 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H19N3O3 |
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| Mol. Mass. | 409.4367 |
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| SMILES | [H][C@]12C[C@]([H])(C=C1)[C@]1([H])C(=O)N(C(=O)[C@]21[H])c1ccc(cc1)C(=O)Nc1cccc2cccnc12 |r,c:5| |
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| Structure | 
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