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TargetE3 ubiquitin-protein ligase Mdm2
LigandBDBM50007649
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1339578 (CHEMBL3243058)
IC50 1.000000±n/a nM
Citation Gonzalez, AZEksterowicz, JBartberger, MDBeck, HPCanon, JChen, AChow, DDuquette, JFox, BMFu, JHuang, XHouze, JBJin, LLi, YLi, ZLing, YLo, MCLong, AMMcGee, LRMcIntosh, JMcMinn, DLOliner, JDOsgood, TRew, YSaiki, AYShaffer, PWortman, SYakowec, PYan, XYe, QYu, DZhao, XZhou, JOlson, SHMedina, JCSun, D Selective and potent morpholinone inhibitors of the MDM2-p53 protein-protein interaction. J Med Chem57:2472-88 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
E3 ubiquitin-protein ligase Mdm2
Name:E3 ubiquitin-protein ligase Mdm2
Synonyms:Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:Oncoprotein
Mol. Mass.:55196.54
Organism:Homo sapiens (Human)
Description:Q00987
Residue:491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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BDBM50007649
n/a
NameBDBM50007649
Synonyms:CHEMBL3233131
TypeSmall organic molecule
Emp. Form.C27H33Cl2NO6S
Mol. Mass.570.525
SMILESCC[C@@H](CS(=O)(=O)CC(C)(C)C)N1[C@@H]([C@H](O[C@H](CC(O)=O)C1=O)c1cccc(Cl)c1)c1ccc(Cl)cc1 |r|
Structure
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