| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 21 |
|---|
| Ligand | BDBM50007791 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1335828 (CHEMBL3239937) |
|---|
| IC50 | >31000±n/a nM |
|---|
| Citation |  Báez-Santos, YM; Barraza, SJ; Wilson, MW; Agius, MP; Mielech, AM; Davis, NM; Baker, SC; Larsen, SD; Mesecar, AD X-ray structural and biological evaluation of a series of potent and highly selective inhibitors of human coronavirus papain-like proteases. J Med Chem57:2393-412 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Ubiquitin carboxyl-terminal hydrolase 21 |
|---|
| Name: | Ubiquitin carboxyl-terminal hydrolase 21 |
|---|
| Synonyms: | Deubiquitinating enzyme 21 | UBP21_HUMAN | USP21 | USP23 | Ubiquitin thioesterase 21 | Ubiquitin-specific-processing protease 21 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 62692.84 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_105198 |
|---|
| Residue: | 565 |
|---|
| Sequence: | MPQASEHRLGRTREPPVNIQPRVGSKLPFAPRARSKERRNPASGPNPMLRPLPPRPGLPD
ERLKKLELGRGRTSGPRPRGPLRADHGVPLPGSPPPTVALPLPSRTNLARSKSVSSGDLR
PMGIALGGHRGTGELGAALSRLALRPEPPTLRRSTSLRRLGGFPGPPTLFSIRTEPPASH
GSFHMISARSSEPFYSDDKMAHHTLLLGSGHVGLRNLGNTCFLNAVLQCLSSTRPLRDFC
LRRDFRQEVPGGGRAQELTEAFADVIGALWHPDSCEAVNPTRFRAVFQKYVPSFSGYSQQ
DAQEFLKLLMERLHLEINRRGRRAPPILANGPVPSPPRRGGALLEEPELSDDDRANLMWK
RYLEREDSKIVDLFVGQLKSCLKCQACGYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCF
NLFTKEEELESENAPVCDRCRQKTRSTKKLTVQRFPRILVLHLNRFSASRGSIKKSSVGV
DFPLQRLSLGDFASDKAGSPVYQLYALCNHSGSVHYGHYTALCRCQTGWHVYNDSRVSPV
SENQVASSEGYVLFYQLMQEPPRCL
|
|
|
|---|
| BDBM50007791 |
|---|
| n/a |
|---|
| Name | BDBM50007791 |
|---|
| Synonyms: | CHEMBL3233815 | med.21724, Compound 168 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C25H27FN2O |
|---|
| Mol. Mass. | 390.4931 |
|---|
| SMILES | C[C@@H](N1CCC(CC1)C(=O)NCc1cccc(F)c1)c1cccc2ccccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
