| Reaction Details |
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 | Report a problem with these data |
| Target | Carboxypeptidase B2 |
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| Ligand | BDBM50008269 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1339183 (CHEMBL3243346) |
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| IC50 | 87±n/a nM |
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| Citation |  Brink, M; Dahlén, A; Olsson, T; Polla, M; Svensson, T Design and synthesis of conformationally restricted inhibitors of active thrombin activatable fibrinolysis inhibitor (TAFIa). Bioorg Med Chem22:2261-8 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carboxypeptidase B2 |
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| Name: | Carboxypeptidase B2 |
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| Synonyms: | CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB |
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| Type: | Enzyme |
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| Mol. Mass.: | 48432.74 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96IY4 |
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| Residue: | 423 |
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| Sequence: | MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV
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| BDBM50008269 |
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| n/a |
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| Name | BDBM50008269 |
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| Synonyms: | CHEMBL3235130 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H14N2O2S |
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| Mol. Mass. | 226.295 |
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| SMILES | C[C@@H](S)[C@@H](Cc1ccc(N)nc1)C(O)=O |r| |
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| Structure | 
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