| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Carboxypeptidase B2 |
|---|
| Ligand | BDBM50008270 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1339183 (CHEMBL3243346) |
|---|
| IC50 | 620±n/a nM |
|---|
| Citation |  Brink, M; Dahlén, A; Olsson, T; Polla, M; Svensson, T Design and synthesis of conformationally restricted inhibitors of active thrombin activatable fibrinolysis inhibitor (TAFIa). Bioorg Med Chem22:2261-8 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Carboxypeptidase B2 |
|---|
| Name: | Carboxypeptidase B2 |
|---|
| Synonyms: | CBPB2_HUMAN | CPB2 | CPU | Carboxypeptidase B2 | Carboxypeptidase B2 isoform A | Carboxypeptidase U | Plasma carboxypeptidase B | TAFI | Thrombin-activable fibrinolysis inhibitor | pCPB |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 48432.74 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96IY4 |
|---|
| Residue: | 423 |
|---|
| Sequence: | MKLCSLAVLVPIVLFCEQHVFAFQSGQVLAALPRTSRQVQVLQNLTTTYEIVLWQPVTAD
LIVKKKQVHFFVNASDVDNVKAHLNVSGIPCSVLLADVEDLIQQQISNDTVSPRASASYY
EQYHSLNEIYSWIEFITERHPDMLTKIHIGSSFEKYPLYVLKVSGKEQAAKNAIWIDCGI
HAREWISPAFCLWFIGHITQFYGIIGQYTNLLRLVDFYVMPVVNVDGYDYSWKKNRMWRK
NRSFYANNHCIGTDLNRNFASKHWCEEGASSSSCSETYCGLYPESEPEVKAVASFLRRNI
NQIKAYISMHSYSQHIVFPYSYTRSKSKDHEELSLVASEAVRAIEKISKNTRYTHGHGSE
TLYLAPGGGDDWIYDLGIKYSFTIELRDTGTYGFLLPERYIKPTCREAFAAVSKIAWHVI
RNV
|
|
|
|---|
| BDBM50008270 |
|---|
| n/a |
|---|
| Name | BDBM50008270 |
|---|
| Synonyms: | CHEMBL3235131 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H20N4O2 |
|---|
| Mol. Mass. | 240.3021 |
|---|
| SMILES | CCCn1cnc(CC(NCCN)C(O)=O)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
