Reaction Details |
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Target | Glycogen phosphorylase, muscle form |
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Ligand | BDBM50009082 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1338433 (CHEMBL3240699) |
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Ki | 670±n/a nM |
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Citation | Kun, S; Bokor, É; Varga, G; Szocs, B; Páhi, A; Czifrák, K; Tóth, M; Juhász, L; Docsa, T; Gergely, P; Somsák, L New synthesis of 3-(ß-D-glucopyranosyl)-5-substituted-1,2,4-triazoles, nanomolar inhibitors of glycogen phosphorylase. Eur J Med Chem76:567-79 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Glycogen phosphorylase, muscle form |
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Name: | Glycogen phosphorylase, muscle form |
Synonyms: | Glycogen Phosphorylase (PYGM) | Glycogen phosphorylase a (RMGPa) | Glycogen phosphorylase, muscle form | Myophosphorylase | PYGM | PYGM_RABIT |
Type: | Enzyme |
Mol. Mass.: | 97296.32 |
Organism: | Oryctolagus cuniculus (rabbit) |
Description: | Phosphorylation of Ser-15 converts phosphorylase B (unphosphorylated) to phosphorylase A. |
Residue: | 843 |
Sequence: | MSRPLSDQEKRKQISVRGLAGVENVTELKKNFNRHLHFTLVKDRNVATPRDYYFALAHTV
RDHLVGRWIRTQQHYYEKDPKRIYYLSLEFYMGRTLQNTMVNLALENACDEATYQLGLDM
EELEEIEEDAGLGNGGLGRLAACFLDSMATLGLAAYGYGIRYEFGIFNQKICGGWQMEEA
DDWLRYGNPWEKARPEFTLPVHFYGRVEHTSQGAKWVDTQVVLAMPYDTPVPGYRNNVVN
TMRLWSAKAPNDFNLKDFNVGGYIQAVLDRNLAENISRVLYPNDNFFEGKELRLKQEYFV
VAATLQDIIRRFKSSKFGCRDPVRTNFDAFPDKVAIQLNDTHPSLAIPELMRVLVDLERL
DWDKAWEVTVKTCAYTNHTVLPEALERWPVHLLETLLPRHLQIIYEINQRFLNRVAAAFP
GDVDRLRRMSLVEEGAVKRINMAHLCIAGSHAVNGVARIHSEILKKTIFKDFYELEPHKF
QNKTNGITPRRWLVLCNPGLAEIIAERIGEEYISDLDQLRKLLSYVDDEAFIRDVAKVKQ
ENKLKFAAYLEREYKVHINPNSLFDVQVKRIHEYKRQLLNCLHVITLYNRIKKEPNKFVV
PRTVMIGGKAAPGYHMAKMIIKLITAIGDVVNHDPVVGDRLRVIFLENYRVSLAEKVIPA
ADLSEQISTAGTEASGTGNMKFMLNGALTIGTMDGANVEMAEEAGEENFFIFGMRVEDVD
RLDQRGYNAQEYYDRIPELRQIIEQLSSGFFSPKQPDLFKDIVNMLMHHDRFKVFADYEE
YVKCQERVSALYKNPREWTRMVIRNIATSGKFSSDRTIAQYAREIWGVEPSRQRLPAPDE
KIP
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BDBM50009082 |
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n/a |
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Name | BDBM50009082 |
Synonyms: | CHEMBL3237972 |
Type | Small organic molecule |
Emp. Form. | C14H18N4O5 |
Mol. Mass. | 322.3165 |
SMILES | Nc1ccc(cc1)-c1n[nH]c(n1)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O |r| |
Structure |
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