| Reaction Details |
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 | Report a problem with these data |
| Target | Gonadotropin-releasing hormone receptor |
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| Ligand | BDBM50261184 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1335046 (CHEMBL3239477) |
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| Ki | 2.2±n/a nM |
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| Citation |  Olberg, DE; Andressen, KW; Levy, FO; Klaveness, J; Haraldsen, I; Sutcliffe, JL Synthesis and in vitro evaluation of small-molecule [18F] labeled gonadotropin-releasing hormone (GnRH) receptor antagonists as potential PET imaging agents for GnRH receptor expression. Bioorg Med Chem Lett24:1846-50 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Gonadotropin-releasing hormone receptor |
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| Name: | Gonadotropin-releasing hormone receptor |
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| Synonyms: | GNRHR_MOUSE | GnRH receptor | GnRH-R | Gnrhr |
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| Type: | PROTEIN |
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| Mol. Mass.: | 37702.59 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_108267 |
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| Residue: | 327 |
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| Sequence: | MANNASLEQDPNHCSAINNSIPLIQGKLPTLTVSGKIRVTVTFFLFLLSTAFNASFLLKL
QKWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYL
KLFSMYAPAFMMVVISLDRSLAITQPLAVQSNSKLEQSMISLAWILSIVFAGPQLYIFRM
IYLADGSGPTVFSQCVTHCSFPQWWHQAFYNFFTFGCLFIIPLLIMLICNAKIIFALTRV
LHQDPRKLQLNQSKNNIPRARLRTLKMTVAFATSFVVCWTPYYVLGIWYWFDPEMLNRVS
EPVNHFFFLFAFLNPCFDPLIYGYFSL
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| BDBM50261184 |
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| n/a |
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| Name | BDBM50261184 |
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| Synonyms: | 5-((3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)methyl)-N-(2,4,6-trimethoxyphenyl)furan-2-carboxamide | CHEMBL494803 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H37NO5 |
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| Mol. Mass. | 491.6185 |
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| SMILES | COc1cc(OC)c(NC(=O)c2ccc(Cc3cc4c(cc3C)C(C)(C)CCC4(C)C)o2)c(OC)c1 |
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| Structure | 
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