| Reaction Details |
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 | Report a problem with these data |
| Target | Chromobox protein homolog 8 |
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| Ligand | BDBM50009463 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1336413 (CHEMBL3242417) |
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| Kd | 12300±n/a nM |
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| Citation |  Simhadri, C; Daze, KD; Douglas, SF; Quon, TT; Dev, A; Gignac, MC; Peng, F; Heller, M; Boulanger, MJ; Wulff, JE; Hof, F Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7). J Med Chem57:2874-83 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Chromobox protein homolog 8 |
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| Name: | Chromobox protein homolog 8 |
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| Synonyms: | CBX8 | CBX8_HUMAN | PC3 | Polycomb 3 homolog | RC1 | Rectachrome 1 | hPc3 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 43415.86 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_108272 |
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| Residue: | 389 |
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| Sequence: | MELSAVGERVFAAEALLKRRIRKGRMEYLVKWKGWSQKYSTWEPEENILDARLLAAFEER
EREMELYGPKKRGPKPKTFLLKAQAKAKAKTYEFRSDSARGIRIPYPGRSPQDLASTSRA
REGLRNMGLSPPASSTSTSSTCRAEAPRDRDRDRDRDRERDRERERERERERERERERER
GTSRVDDKPSSPGDSSKKRGPKPRKELPDPSQRPLGEPSAGLGEYLKGRKLDDTPSGAGK
FPAGHSVIQLARRQDSDLVQCGVTSPSSAEATGKLAVDTFPARVIKHRAAFLEAKGQGAL
DPNGTRVRHGSGPPSSGGGLYRDMGAQGGRPSLIARIPVARILGDPEEESWSPSLTNLEK
VVVTDVTSNFLTVTIKESNTDQGFFKEKR
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| BDBM50009463 |
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| n/a |
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| Name | BDBM50009463 |
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| Synonyms: | CHEMBL3234145 |
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| Type | Small organic molecule |
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| Emp. Form. | C35H52N7O8 |
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| Mol. Mass. | 698.8289 |
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| SMILES | C[C@H](NC(=O)[C@H](Cc1ccccc1)NC(C)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCC[N+](C)(C)C)C(=O)N[C@@H](CO)C(N)=O |r| |
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| Structure | 
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