Reaction Details |
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Target | Dihydrofolate reductase |
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Ligand | BDBM50010232 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1341015 (CHEMBL3254994) |
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IC50 | 300±n/a nM |
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Citation | Martinelli, JE; Chaykovsky, M; Kisliuk, RL; Gaumont, Y; Gittelman, MC Methotrexate analogues. 12. Synthesis and biological properties of some aza homologues. J Med Chem22:869-74 (1979) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Dihydrofolate reductase |
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Name: | Dihydrofolate reductase |
Synonyms: | DYR_LACCA | dhfR | folA |
Type: | PROTEIN |
Mol. Mass.: | 18437.08 |
Organism: | Lactobacillus casei |
Description: | ChEMBL_1357878 |
Residue: | 163 |
Sequence: | MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN
VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA
GSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
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BDBM50010232 |
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n/a |
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Name | BDBM50010232 |
Synonyms: | CHEMBL3245587 |
Type | Small organic molecule |
Emp. Form. | C22H27N9O5 |
Mol. Mass. | 497.5071 |
SMILES | COC(=O)CC[C@H](NC(=O)Nc1ccc(cc1)N(C)Cc1cnc2nc(N)nc(N)c2n1)C(=O)OC |r| |
Structure |
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