| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50010234 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1341015 (CHEMBL3254994) |
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| IC50 | 80±n/a nM |
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| Citation |  Martinelli, JE; Chaykovsky, M; Kisliuk, RL; Gaumont, Y; Gittelman, MC Methotrexate analogues. 12. Synthesis and biological properties of some aza homologues. J Med Chem22:869-74 (1979) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_LACCA | dhfR | folA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 18437.08 |
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| Organism: | Lactobacillus casei |
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| Description: | ChEMBL_1357878 |
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| Residue: | 163 |
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| Sequence: | MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN
VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA
GSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
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| BDBM50010234 |
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| n/a |
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| Name | BDBM50010234 |
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| Synonyms: | CHEMBL3245589 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23N9O5 |
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| Mol. Mass. | 469.4539 |
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| SMILES | CN(Cc1cnc2nc(N)nc(N)c2n1)c1ccc(NC(=O)NC(CCC(O)=O)C(O)=O)cc1 |
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| Structure | 
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