Reaction Details |
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Target | Monoacylglycerol lipase ABHD6 |
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Ligand | BDBM50010336 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1352835 (CHEMBL3269007) |
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IC50 | 0.200000±n/a nM |
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Citation | Chang, JW; Hsu, KL; Tsuboi, K; Whitby, LR; Pugh, H Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of a/ß-hydrolase domain containing 6 (ABHD6). Cell Chem Biol56:8270-9 (2013) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Monoacylglycerol lipase ABHD6 |
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Name: | Monoacylglycerol lipase ABHD6 |
Synonyms: | ABHD6_MOUSE | Abh6 | Abhd6 | Abhydrolase Domain-Containing Protein 6 | Monoacylglycerol lipase ABHD6 |
Type: | Single-pass type II membrane protein; hydrolase |
Mol. Mass.: | 38216.17 |
Organism: | Mus musculus (mouse) |
Description: | Assays were using membranes of recombinant Abh6 transiently transfected in COS-7 cells. |
Residue: | 336 |
Sequence: | MDLDVVNMFVIAGGTLAIPILAFVASFLLWPSALIRIYYWYWRRTLGMQVRYAHHEDYQF
CYSFRGRPGHKPSILMLHGFSAHKDMWLSVVKFLPKNLHLVCVDMPGHEGTTRSSLDDLS
IVGQVKRIHQFVECLKLNKKPFHLIGTSMGGHVAGVYAAYYPSDVCSLSLVCPAGLQYST
DNPFVQRLKELEESAAIQKIPLIPSTPEEMSEMLQLCSYVRFKVPQQILQGLVDVRIPHN
SFYRKLFLEIVNEKSRYSLHENMDKIKVPTQIIWGKQDQVLDVSGADILAKSISNSQVEV
LENCGHSVVMERPRKTAKLIVDFLASVHNTDNKKLN
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BDBM50010336 |
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n/a |
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Name | BDBM50010336 |
Synonyms: | CHEMBL3263579 |
Type | Small organic molecule |
Emp. Form. | C32H33N5O2 |
Mol. Mass. | 519.6367 |
SMILES | O=C(N1CCCCC1)c1cccc(c1)-c1ccc(cc1)-c1cn(nn1)C(=O)N1CCCCC1c1ccccc1 |
Structure |
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