| Reaction Details |
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 | Report a problem with these data |
| Target | DNA gyrase subunit B |
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| Ligand | BDBM50010373 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1353018 (CHEMBL3270626) |
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| IC50 | 1.000000±n/a nM |
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| Citation |  Ahuja, V; Basavarajappa, H; P, SH; Boriack-Sjodin, PA; McKinney, D; Ganguly, S; Kranthi, U; Gaonkar, S; Jena, Lk; Ghorpade, SR; Ghosh, A; Barde, S; Kale, MG; Koushik, K; Kumar, CN; Manjunatha, MR; Ogg, D; Panduga, V; Ramya, VK; Reddy, J; Kumar, KN; Giridhar, J; Rudrapatna, S; Sharma, S; Tucker, JA; Vachaspati, P; Waterson, D; de Sousa, SM Thiazolopyridine ureas as novel antitubercular agents acting through inhibition of DNA Gyrase B. Cell Chem Biol56:8834-48 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA gyrase subunit B |
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| Name: | DNA gyrase subunit B |
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| Synonyms: | GYRB_MYCSM | gyrB |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74505.25 |
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| Organism: | Mycobacterium smegmatis |
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| Description: | ChEMBL_107961 |
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| Residue: | 675 |
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| Sequence: | MAAQKNNAPKEYGADSITILEGLEAVRKRPGMYIGSTGERGLHHLIWEVVDNAVDEAMAG
FATRVDVKIHADGSVEVRDDGRGIPVEMHATGMPTIDVVMTQLHAGGKFDGETYAVSGGL
HGVGVSVVNALSTRLEATVLRDGYEWFQYYDRSVPGKLKQGGETKETGTTIRFWADPEIF
ETTDYNFETVARRLQEMAFLNKGLTIELTDERVTAEEVVDDVVKDTAEAPKTADEKAAEA
TGPSKVKHRVFHYPGGLVDYVKHINRTKTPIQQSIIDFDGKGPGHEVEIAMQWNAGYSES
VHTFANTINTHEGGTHEEGFRAALTSVVNRYAKDKKLLKDKDPNLTGDDIREGLAAVISV
KVAEPQFEGQTKTKLGNTEVKSFVQKICNEQLQHWFEANPAEAKTVVNKAVSSAQARIAA
RKARELVRRKSATDIGGLPGKLADCRSTDPSKSELYVVEGDSAGGSAKSGRDSMFQAILP
LRGKIINVEKARIDRVLKNTEVQSIITALGTGIHDEFDISKLRYHKIVLMADADVDGQHI
STLLLTLLFRFMKPLVENGHIFLAQPPLYKLKWQRSEPEFAYSDRERDGLLEAGRAAGKK
INVDDGIQRYKGLGEMDAKELWETTMDPSVRVLRQVTLDDAAAADELFSILMGEDVEARR
SFITRNAKDVRFLDV
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| BDBM50010373 |
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| n/a |
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| Name | BDBM50010373 |
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| Synonyms: | CHEMBL3263615 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H23N5O4S |
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| Mol. Mass. | 429.493 |
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| SMILES | CCNC(=O)Nc1nc2cc(-c3ccn(C)c(=O)c3)c(OCC3CCOC3)nc2s1 |
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| Structure | 
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