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TargetHuman immunodeficiency virus type 1 integrase
LigandBDBM50011011
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1351354
Kd 140±n/a nM
Citation Fader LDMalenfant EParisien MCarson RBilodeau FLandry SPesant MBrochu CMorin SChabot CHalmos TBousquet YBailey MDKawai SHCoulombe RLaPlante SJakalian ABhardwaj PKWernic DSchroeder PAmad MEdwards PGarneau MDuan JCordingley MBethell RMason SWBös MBonneau PPoupart MAFaucher AMSimoneau BFenwick CYoakim CTsantrizos Y Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1. ACS Med Chem Lett 5:422-7 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Human immunodeficiency virus type 1 integrase
Name:Human immunodeficiency virus type 1 integrase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:32231.48
Organism:Human immunodeficiency virus 1
Description:ChEMBL_90865
Residue:288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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  Blast E-value cutoff:
BDBM50011011
n/a
NameBDBM50011011
Synonyms:CHEMBL3259900
TypeSmall organic molecule
Emp. Form.C22H21Cl2NO3
Mol. Mass.418.313
SMILESCc1nc2cc(Cl)ccc2c(-c2ccc(Cl)cc2)c1[C@H](OC(C)(C)C)C(O)=O |r|
Structure
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