| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50011129 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1351355 (CHEMBL3266568) |
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| IC50 | 3100±n/a nM |
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| Citation |  Fader, LD; Malenfant, E; Parisien, M; Carson, R; Bilodeau, F; Landry, S; Pesant, M; Brochu, C; Morin, S; Chabot, C; Halmos, T; Bousquet, Y; Bailey, MD; Kawai, SH; Coulombe, R; LaPlante, S; Jakalian, A; Bhardwaj, PK; Wernic, D; Schroeder, P; Amad, M; Edwards, P; Garneau, M; Duan, J; Cordingley, M; Bethell, R; Mason, SW; Bös, M; Bonneau, P; Poupart, MA; Faucher, AM; Simoneau, B; Fenwick, C; Yoakim, C; Tsantrizos, Y Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1. ACS Med Chem Lett5:422-7 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | Human immunodeficiency virus type 1 integrase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32231.48 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_90865 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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| BDBM50011129 |
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| n/a |
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| Name | BDBM50011129 |
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| Synonyms: | CHEMBL3259888 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14ClNO2 |
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| Mol. Mass. | 311.762 |
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| SMILES | Cc1nc2ccccc2c(-c2ccc(Cl)cc2)c1CC(O)=O |
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| Structure | 
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