| Reaction Details |
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 | Report a problem with these data |
| Target | Mitotic checkpoint serine/threonine-protein kinase BUB1 |
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| Ligand | BDBM50011200 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1351814 (CHEMBL3271320) |
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| IC50 | 500±n/a nM |
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| Citation |  Brazeau, JF; Rosse, G Novel cycloalkenepyrazoles as inhibitors of bub1 kinase. ACS Med Chem Lett5:280-1 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitotic checkpoint serine/threonine-protein kinase BUB1 |
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| Name: | Mitotic checkpoint serine/threonine-protein kinase BUB1 |
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| Synonyms: | BUB1 | BUB1A | BUB1L | BUB1_HUMAN | hBUB1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 122372.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1510603 |
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| Residue: | 1085 |
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| Sequence: | MDTPENVLQMLEAHMQSYKGNDPLGEWERYIQWVEENFPENKEYLITLLEHLMKEFLDKK
KYHNDPRFISYCLKFAEYNSDLHQFFEFLYNHGIGTLSSPLYIAWAGHLEAQGELQHASA
VLQRGIQNQAEPREFLQQQYRLFQTRLTETHLPAQARTSEPLHNVQVLNQMITSKSNPGN
NMACISKNQGSELSGVISSACDKESNMERRVITISKSEYSVHSSLASKVDVEQVVMYCKE
KLIRGESEFSFEELRAQKYNQRRKHEQWVNEDRHYMKRKEANAFEEQLLKQKMDELHKKL
HQVVETSHEDLPASQERSEVNPARMGPSVGSQQELRAPCLPVTYQQTPVNMEKNPREAPP
VVPPLANAISAALVSPATSQSIAPPVPLKAQTVTDSMFAVASKDAGCVNKSTHEFKPQSG
AEIKEGCETHKVANTSSFHTTPNTSLGMVQATPSKVQPSPTVHTKEALGFIMNMFQAPTL
PDISDDKDEWQSLDQNEDAFEAQFQKNVRSSGAWGVNKIISSLSSAFHVFEDGNKENYGL
PQPKNKPTGARTFGERSVSRLPSKPKEEVPHAEEFLDDSTVWGIRCNKTLAPSPKSPGDF
TSAAQLASTPFHKLPVESVHILEDKENVVAKQCTQATLDSCEENMVVPSRDGKFSPIQEK
SPKQALSSHMYSASLLRLSQPAAGGVLTCEAELGVEACRLTDTDAAIAEDPPDAIAGLQA
EWMQMSSLGTVDAPNFIVGNPWDDKLIFKLLSGLSKPVSSYPNTFEWQCKLPAIKPKTEF
QLGSKLVYVHHLLGEGAFAQVYEATQGDLNDAKNKQKFVLKVQKPANPWEFYIGTQLMER
LKPSMQHMFMKFYSAHLFQNGSVLVGELYSYGTLLNAINLYKNTPEKVMPQGLVISFAMR
MLYMIEQVHDCEIIHGDIKPDNFILGNGFLEQDDEDDLSAGLALIDLGQSIDMKLFPKGT
IFTAKCETSGFQCVEMLSNKPWNYQIDYFGVAATVYCMLFGTYMKVKNEGGECKPEGLFR
RLPHLDMWNEFFHVMLNIPDCHHLPSLDLLRQKLKKVFQQHYTNKIRALRNRLIVLLLEC
KRSRK
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| BDBM50011200 |
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| n/a |
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| Name | BDBM50011200 |
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| Synonyms: | CHEMBL3260327 |
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| Type | Small organic molecule |
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| Emp. Form. | C34H31FN6O5 |
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| Mol. Mass. | 622.6455 |
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| SMILES | CCOC(=O)c1cnccc1Nc1nc(ncc1Oc1ccccc1C(=O)OCC)-c1nn(Cc2ccccc2F)c2CCCc12 |
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| Structure | 
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