| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Plasma kallikrein |
|---|
| Ligand | BDBM50011242 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1351825 (CHEMBL3271331) |
|---|
| Ki | 3.0±n/a nM |
|---|
| Citation |  Abdel-Magid, AF Inhibitors of Factor XIa and Plasma Kallikrein May Treat Thromboembolic Disorders and Many Diabetes Complications. ACS Med Chem Lett5:286-7 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Plasma kallikrein |
|---|
| Name: | Plasma kallikrein |
|---|
| Synonyms: | Fletcher factor | KLK3 | KLKB1 | KLKB1_HUMAN | Kallikrein | Kininogenin | Plasma kallikrein heavy chain | Plasma kallikrein light chain | Plasma prekallikrein |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 71391.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P03952 |
|---|
| Residue: | 638 |
|---|
| Sequence: | MILFKQATYFISLFATVSCGCLTQLYENAFFRGGDVASMYTPNAQYCQMRCTFHPRCLLF
SFLPASSINDMEKRFGCFLKDSVTGTLPKVHRTGAVSGHSLKQCGHQISACHRDIYKGVD
MRGVNFNVSKVSSVEECQKRCTSNIRCQFFSYATQTFHKAEYRNNCLLKYSPGGTPTAIK
VLSNVESGFSLKPCALSEIGCHMNIFQHLAFSDVDVARVLTPDAFVCRTICTYHPNCLFF
TFYTNVWKIESQRNVCLLKTSESGTPSSSTPQENTISGYSLLTCKRTLPEPCHSKIYPGV
DFGGEELNVTFVKGVNVCQETCTKMIRCQFFTYSLLPEDCKEEKCKCFLRLSMDGSPTRI
AYGTQGSSGYSLRLCNTGDNSVCTTKTSTRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCG
GSLIGHQWVLTAAHCFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEG
NHDIALIKLQAPLNYTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNI
PLVTNEECQKRYQDYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGE
GCARREQPGVYTKVAEYMDWILEKTQSSDGKAQMQSPA
|
|
|
|---|
| BDBM50011242 |
|---|
| n/a |
|---|
| Name | BDBM50011242 |
|---|
| Synonyms: | CHEMBL3260339 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H29BrClFN4O4 |
|---|
| Mol. Mass. | 655.942 |
|---|
| SMILES | COC(=O)Nc1ccc-2c(NC(=O)[C@H](C)CCC[C@H](N3CCC(=CC3=O)c3c(Br)ccc(Cl)c3F)c3cc-2ccn3)c1 |r,c:22| |
|---|
| Structure | 
|
|---|
Search and Browse
