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TargetCannabinoid receptor 1
LigandBDBM50011313
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1352142 (CHEMBL3267751)
Ki 28±n/a nM
Citation Ellsworth, BASher, PMWu, XWu, GSulsky, RBGu, ZMurugesan, NZhu, YYu, GSitkoff, DFCarlson, KEKang, LYang, YLee, NBaska, RAKeim, WJCullen, MJAzzara, AVZuvich, EThomas, MARohrbach, KWDevenny, JJGodonis, HEHarvey, SJMurphy, BJEverlof, GGStetsko, PIGudmundsson, OJohnghar, SRanasinghe, ABehnia, KPelleymounter, MAEwing, WR Reductions in log P improved protein binding and clearance predictions enabling the prospective design of cannabinoid receptor (CB1) antagonists with desired pharmacokinetic properties. J Med Chem56:9586-600 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cannabinoid receptor 1
Name:Cannabinoid receptor 1
Synonyms:CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:52868.96
Organism:Homo sapiens (Human)
Description:P21554
Residue:472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQE
KMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIA
VLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVF
HRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLM
WTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWK
AHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLL
AIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQ
PLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50011313
n/a
NameBDBM50011313
Synonyms:CHEMBL3260740
TypeSmall organic molecule
Emp. Form.C24H16ClF3N6O2
Mol. Mass.512.871
SMILESCn1nc2c(-c3ccc(Cl)cc3)c(-c3ccncc3)c(=O)n(Cc3ccc(nc3)C(F)(F)F)n2c1=O
Structure
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