| Reaction Details |
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 | Report a problem with these data |
| Target | Rap guanine nucleotide exchange factor 4 |
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| Ligand | BDBM50011368 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1352339 (CHEMBL3269756) |
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| IC50 | 600±n/a nM |
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| Citation |  Chen, H; Wild, C; Zhou, X; Ye, N; Cheng, X; Zhou, J Recent advances in the discovery of small molecules targeting exchange proteins directly activated by cAMP (EPAC). J Med Chem57:3651-65 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Rap guanine nucleotide exchange factor 4 |
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| Name: | Rap guanine nucleotide exchange factor 4 |
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| Synonyms: | CGEF2 | EPAC 2 | EPAC2 | Exchange factor directly activated by cAMP 2 | Exchange protein directly activated by cAMP 2 | RAPGEF4 | RPGF4_HUMAN | cAMP-GEFII | cAMP-regulated guanine nucleotide exchange factor II |
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| Type: | PROTEIN |
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| Mol. Mass.: | 115526.83 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1504794 |
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| Residue: | 1011 |
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| Sequence: | MVAAHAAHSSSSAEWIACLDKRPLERSSEDVDIIFTRLKEVKAFEKFHPNLLHQICLCGY
YENLEKGITLFRQGDIGTNWYAVLAGSLDVKVSETSSHQDAVTICTLGIGTAFGESILDN
TPRHATIVTRESSELLRIEQKDFKALWEKYRQYMAGLLAPPYGVMETGSNNDRIPDKENT
PLIEPHVPLRPANTITKVPSEKILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTE
LVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEHHFQDKYLFYRFLDDEHEDAPLP
TEEEKKECDEELQDTMLLLSQMGPDAHMRMILRKPPGQRTVDDLEIIYEELLHIKALSHL
STTVKRELAGVLIFESHAKGGTVLFNQGEEGTSWYIILKGSVNVVIYGKGVVCTLHEGDD
FGKLALVNDAPRAASIVLREDNCHFLRVDKEDFNRILRDVEANTVRLKEHDQDVLVLEKV
PAGNRASNQGNSQPQQKYTVMSGTPEKILEHFLETIRLEATLNEATDSVLNDFIMMHCVF
MPNTQLCPALVAHYHAQPSQGTEQEKMDYALNNKRRVIRLVLQWAAMYGDLLQEDDVSMA
FLEEFYVSVSDDARMIAALKEQLPELEKIVKQISEDAKAPQKKHKVLLQQFNTGDERAQK
RQPIRGSDEVLFKVYCMDHTYTTIRVPVATSVKEVISAVADKLGSGEGLIIVKMSSGGEK
VVLKPNDVSVFTTLTINGRLFACPREQFDSLTPLPEQEGPTVGTVGTFELMSSKDLAYQM
TIYDWELFNCVHELELIYHTFGRHNFKKTTANLDLFLRRFNEIQFWVVTEICLCSQLSKR
VQLLKKFIKIAAHCKEYKNLNSFFAIVMGLSNVAVSRLALTWEKLPSKFKKFYAEFESLM
DPSRNHRAYRLTVAKLEPPLIPFMPLLIKDMTFTHEGNKTFIDNLVNFEKMRMIANTART
VRYYRSQPFNPDAAQANKNHQDVRSYVRQLNVIDNQRTLSQMSHRLEPRRP
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| BDBM50011368 |
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| n/a |
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| Name | BDBM50011368 |
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| Synonyms: | CHEMBL3260989 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H25IN2OS |
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| Mol. Mass. | 432.363 |
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| SMILES | [I-].COCCC[n+]1c(C)csc1Nc1c(C)cc(C)cc1C |
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| Structure | 
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