| Reaction Details |
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 | Report a problem with these data |
| Target | Translocator protein |
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| Ligand | BDBM22040 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1352881 (CHEMBL3269398) |
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| Ki | 23±n/a nM |
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| Citation |  Castellano, S; Taliani, S; Viviano, M; Milite, C; Da Pozzo, E; Costa, B; Barresi, E; Bruno, A; Cosconati, S; Marinelli, L; Greco, G; Novellino, E; Sbardella, G; Da Settimo, F; Martini, C Structure-activity relationship refinement and further assessment of 4-phenylquinazoline-2-carboxamide translocator protein ligands as antiproliferative agents in human glioblastoma tumors. J Med Chem57:2413-28 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Translocator protein |
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| Name: | Translocator protein |
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| Synonyms: | Benzodiazepine receptors; peripheral & central | Bzrp | Mbr | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral benzodiazepine receptor (PBR) | Peripheral-Type Benzodiazepine Receptor | TSPO_RAT | Tspo |
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| Type: | Mitochondrion membrane protein |
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| Mol. Mass.: | 18945.84 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Competitive binding experiments were performed on rat kidney mitochondrial membranes. |
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| Residue: | 169 |
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| Sequence: | MSQSWVPAVGLTLVPSLGGFMGAYFVRGEGLRWYASLQKPSWHPPRWTLAPIWGTLYSAM
GYGSYIIWKELGGFTEEAMVPLGLYTGQLALNWAWPPIFFGARQMGWALVDLMLVSGVAT
ATTLAWHRVSPPAARLLYPYLAWLAFATMLNYYVWRDNSGRRGGSRLTE
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| BDBM22040 |
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| n/a |
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| Name | BDBM22040 |
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| Synonyms: | 4 -chlorodiazepam | 4' Cl-diazepam | 7-chloro-5-(4-chlorophenyl)-1-methyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one | 7-chloro-5-(4-chlorophenyl)-1-methyl-2,3-dihydro-1H-1,4-benzodiazepin-2-one | CHEMBL286346 | Ro 5-4864 | Ro-05-4864 | Ro-4864 | Ro5-4864 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H12Cl2N2O |
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| Mol. Mass. | 319.185 |
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| SMILES | CN1c2ccc(Cl)cc2C(=NCC1=O)c1ccc(Cl)cc1 |c:10| |
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| Structure | 
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