Reaction Details |
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Target | Penicillin-binding protein 1A |
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Ligand | BDBM50240480 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1353117 (CHEMBL3271797) |
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IC50 | 3340±n/a nM |
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Citation | Starr, J; Brown, MF; Aschenbrenner, L; Caspers, N; Che, Y; Gerstenberger, BS; Huband, M; Knafels, JD; Lemmon, MM; Li, C; McCurdy, SP; McElroy, E; Rauckhorst, MR; Tomaras, AP; Young, JA; Zaniewski, RP; Shanmugasundaram, V; Han, S Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria. J Med Chem57:3845-55 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Penicillin-binding protein 1A |
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Name: | Penicillin-binding protein 1A |
Synonyms: | DD-transpeptidase | PBP-1a | PBP1a | PBPA_PSEAE | Penicillin-insensitive transglycosylase | Penicillin-sensitive transpeptidase | Peptidoglycan TGase | mrcA | ponA |
Type: | PROTEIN |
Mol. Mass.: | 91195.42 |
Organism: | Pseudomonas aeruginosa PAO1 |
Description: | ChEMBL_108353 |
Residue: | 822 |
Sequence: | MRLLKFLWWTCVTLICGVLLSFSGAYLYLSPSLPSVEALRNVQLQIPLKVYSEDGKLISE
FGEMRRTPIRFADIPQDFIHALLSAEDDNFANHYGVDVKSLMRAAAQLLKSGHIQTGGST
ITMQVAKNYFLTNERSFSRKINEILLALQIERQLTKDEILELYVNKIYLGNRAYGIEAAA
QVYYGKPIKDLSLAEMAMIAGLPKAPSRYNPLVNPTRSTERRNWILERMLKLGFIDQQRY
QAAVEEPINASYHVQTPELNAPYIAEMARAEMVGRYGSEAYTEGYKVITTVRSDLQNAAS
QSVRDGLIDYDQRHGYRGPETRLPGQTRDAWLKHLGQQRSIGGLEPAIVTQVEKSGIMVM
TRDGKEEAVTWDSMKWARPFLSNNSMGPMPRQPADVAQAGDQIRVQRQEDGTLRFVQIPA
AQSALISLDPKDGAIRSLVGGFSFEQSNYNRAIQAKRQPGSSFKPFIYSAALDNGFTAAS
LVNDAPIVFVDEYLDKVWRPKNDTNTFLGPIPLREALYKSRNMVSIRVLQGLGIERAISY
ITKFGFQRDELPRNFSLALGTATVTPMEIAGAWSVFANGGYKVNPYVIERIESRDGQVLY
QANPPRVPVEEQVAADAEDAGNPGDPEHPESAEGEGSIEAQQVAAKAQTTFEPTPAERII
DARTAYIMTSMLQDVIKRGTGRRALALKRTDLAGKTGTTNDSKDGWFSGYNSDYVTSVWV
GFDQPETLGRREYGGTVALPIWIRYMGFALKDKPMHTMAEPPGIVSLRIDPVTGRSAAPG
TPGAYFEMFKNEDTPPSVNELPPGSFPGSPLPDDEGAPIDLF
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BDBM50240480 |
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n/a |
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Name | BDBM50240480 |
Synonyms: | (2S,3S)-3-({(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]ethanoyl}amino)-2-methyl-4-oxoazetidine-1-sulfonate | (2S,3S)-3-({(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]ethanoyl}amino)-2-methyl-4-oxoazetidine-1-sulfonate(aztreonam) | 2-[1-(2-Amino-thiazol-4-yl)-1-((2S,3S)-2-methyl-4-oxo-1-sulfo-azetidin-3-ylcarbamoyl)-meth-(Z)-ylideneaminooxy]-2-methyl-propionic acid | AZTREONAM | Azactam | Azetreonam | CHEMBL158 | SQ-26776 |
Type | Small organic molecule |
Emp. Form. | C13H17N5O8S2 |
Mol. Mass. | 435.433 |
SMILES | C[C@H]1[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)\c2csc(N)n2)C(=O)N1S(O)(=O)=O |r| |
Structure |
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