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TargetPenicillin-binding protein 1A
LigandBDBM50240480
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1353117 (CHEMBL3271797)
IC50 3340±n/a nM
Citation Starr, JBrown, MFAschenbrenner, LCaspers, NChe, YGerstenberger, BSHuband, MKnafels, JDLemmon, MMLi, CMcCurdy, SPMcElroy, ERauckhorst, MRTomaras, APYoung, JAZaniewski, RPShanmugasundaram, VHan, S Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria. J Med Chem57:3845-55 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Penicillin-binding protein 1A
Name:Penicillin-binding protein 1A
Synonyms:DD-transpeptidase | PBP-1a | PBP1a | PBPA_PSEAE | Penicillin-insensitive transglycosylase | Penicillin-sensitive transpeptidase | Peptidoglycan TGase | mrcA | ponA
Type:PROTEIN
Mol. Mass.:91195.42
Organism:Pseudomonas aeruginosa PAO1
Description:ChEMBL_108353
Residue:822
Sequence:
MRLLKFLWWTCVTLICGVLLSFSGAYLYLSPSLPSVEALRNVQLQIPLKVYSEDGKLISE
FGEMRRTPIRFADIPQDFIHALLSAEDDNFANHYGVDVKSLMRAAAQLLKSGHIQTGGST
ITMQVAKNYFLTNERSFSRKINEILLALQIERQLTKDEILELYVNKIYLGNRAYGIEAAA
QVYYGKPIKDLSLAEMAMIAGLPKAPSRYNPLVNPTRSTERRNWILERMLKLGFIDQQRY
QAAVEEPINASYHVQTPELNAPYIAEMARAEMVGRYGSEAYTEGYKVITTVRSDLQNAAS
QSVRDGLIDYDQRHGYRGPETRLPGQTRDAWLKHLGQQRSIGGLEPAIVTQVEKSGIMVM
TRDGKEEAVTWDSMKWARPFLSNNSMGPMPRQPADVAQAGDQIRVQRQEDGTLRFVQIPA
AQSALISLDPKDGAIRSLVGGFSFEQSNYNRAIQAKRQPGSSFKPFIYSAALDNGFTAAS
LVNDAPIVFVDEYLDKVWRPKNDTNTFLGPIPLREALYKSRNMVSIRVLQGLGIERAISY
ITKFGFQRDELPRNFSLALGTATVTPMEIAGAWSVFANGGYKVNPYVIERIESRDGQVLY
QANPPRVPVEEQVAADAEDAGNPGDPEHPESAEGEGSIEAQQVAAKAQTTFEPTPAERII
DARTAYIMTSMLQDVIKRGTGRRALALKRTDLAGKTGTTNDSKDGWFSGYNSDYVTSVWV
GFDQPETLGRREYGGTVALPIWIRYMGFALKDKPMHTMAEPPGIVSLRIDPVTGRSAAPG
TPGAYFEMFKNEDTPPSVNELPPGSFPGSPLPDDEGAPIDLF
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BDBM50240480
n/a
NameBDBM50240480
Synonyms:(2S,3S)-3-({(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]ethanoyl}amino)-2-methyl-4-oxoazetidine-1-sulfonate | (2S,3S)-3-({(2Z)-2-(2-ammonio-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]ethanoyl}amino)-2-methyl-4-oxoazetidine-1-sulfonate(aztreonam) | 2-[1-(2-Amino-thiazol-4-yl)-1-((2S,3S)-2-methyl-4-oxo-1-sulfo-azetidin-3-ylcarbamoyl)-meth-(Z)-ylideneaminooxy]-2-methyl-propionic acid | AZTREONAM | Azactam | Azetreonam | CHEMBL158 | SQ-26776
TypeSmall organic molecule
Emp. Form.C13H17N5O8S2
Mol. Mass.435.433
SMILESC[C@H]1[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)\c2csc(N)n2)C(=O)N1S(O)(=O)=O |r|
Structure
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