| Reaction Details |
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 | Report a problem with these data |
| Target | Penicillin-binding protein 1A |
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| Ligand | BDBM50012177 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1353117 (CHEMBL3271797) |
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| IC50 | 30±n/a nM |
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| Citation |  Starr, J; Brown, MF; Aschenbrenner, L; Caspers, N; Che, Y; Gerstenberger, BS; Huband, M; Knafels, JD; Lemmon, MM; Li, C; McCurdy, SP; McElroy, E; Rauckhorst, MR; Tomaras, AP; Young, JA; Zaniewski, RP; Shanmugasundaram, V; Han, S Siderophore receptor-mediated uptake of lactivicin analogues in gram-negative bacteria. J Med Chem57:3845-55 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Penicillin-binding protein 1A |
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| Name: | Penicillin-binding protein 1A |
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| Synonyms: | DD-transpeptidase | PBP-1a | PBP1a | PBPA_PSEAE | Penicillin-insensitive transglycosylase | Penicillin-sensitive transpeptidase | Peptidoglycan TGase | mrcA | ponA |
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| Type: | PROTEIN |
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| Mol. Mass.: | 91195.42 |
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| Organism: | Pseudomonas aeruginosa PAO1 |
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| Description: | ChEMBL_108353 |
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| Residue: | 822 |
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| Sequence: | MRLLKFLWWTCVTLICGVLLSFSGAYLYLSPSLPSVEALRNVQLQIPLKVYSEDGKLISE
FGEMRRTPIRFADIPQDFIHALLSAEDDNFANHYGVDVKSLMRAAAQLLKSGHIQTGGST
ITMQVAKNYFLTNERSFSRKINEILLALQIERQLTKDEILELYVNKIYLGNRAYGIEAAA
QVYYGKPIKDLSLAEMAMIAGLPKAPSRYNPLVNPTRSTERRNWILERMLKLGFIDQQRY
QAAVEEPINASYHVQTPELNAPYIAEMARAEMVGRYGSEAYTEGYKVITTVRSDLQNAAS
QSVRDGLIDYDQRHGYRGPETRLPGQTRDAWLKHLGQQRSIGGLEPAIVTQVEKSGIMVM
TRDGKEEAVTWDSMKWARPFLSNNSMGPMPRQPADVAQAGDQIRVQRQEDGTLRFVQIPA
AQSALISLDPKDGAIRSLVGGFSFEQSNYNRAIQAKRQPGSSFKPFIYSAALDNGFTAAS
LVNDAPIVFVDEYLDKVWRPKNDTNTFLGPIPLREALYKSRNMVSIRVLQGLGIERAISY
ITKFGFQRDELPRNFSLALGTATVTPMEIAGAWSVFANGGYKVNPYVIERIESRDGQVLY
QANPPRVPVEEQVAADAEDAGNPGDPEHPESAEGEGSIEAQQVAAKAQTTFEPTPAERII
DARTAYIMTSMLQDVIKRGTGRRALALKRTDLAGKTGTTNDSKDGWFSGYNSDYVTSVWV
GFDQPETLGRREYGGTVALPIWIRYMGFALKDKPMHTMAEPPGIVSLRIDPVTGRSAAPG
TPGAYFEMFKNEDTPPSVNELPPGSFPGSPLPDDEGAPIDLF
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| BDBM50012177 |
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| n/a |
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| Name | BDBM50012177 |
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| Synonyms: | CHEMBL3265226 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H22N6O14S |
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| Mol. Mass. | 662.539 |
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| SMILES | CC(C)(O\N=C(/C(=O)N[C@H]1CON(C1=O)C1(C[C@H](N2C(=O)c3cc(O)c(O)cc3C2=O)C(=O)O1)C(O)=O)c1csc(N)n1)C(O)=O |r| |
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| Structure | 
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