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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | E3 ubiquitin-protein ligase Mdm2 | ||
| Ligand | BDBM50012588 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1351457 (CHEMBL3267322) | ||
| IC50 | 3.0±n/a nM | ||
| Citation |  Vaupel, A; Bold, G; De Pover, A; Stachyra-Valat, T; Hergovich-Lisztwan, J; Kallen, J; Masuya, K; Furet, P Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction. Bioorg Med Chem Lett24:2110-4 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| E3 ubiquitin-protein ligase Mdm2 | |||
| Name: | E3 ubiquitin-protein ligase Mdm2 | ||
| Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein | ||
| Type: | Oncoprotein | ||
| Mol. Mass.: | 55196.54 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q00987 | ||
| Residue: | 491 | ||
| Sequence: |
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| BDBM50012588 | |||
| n/a | |||
| Name | BDBM50012588 | ||
| Synonyms: | CHEMBL3260813 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H12Cl2F2N2O2 | ||
| Mol. Mass. | 445.246 | ||
| SMILES | OC(=O)c1nc(-c2ccccc2)n(c1-c1ccc(F)c(Cl)c1)-c1cccc(Cl)c1F |(7.47,-12.21,;6.8,-13.6,;5.26,-13.71,;7.66,-14.88,;9.2,-14.93,;9.63,-16.41,;11.07,-16.94,;11.33,-18.46,;12.78,-18.99,;13.96,-18,;13.69,-16.48,;12.25,-15.95,;8.35,-17.27,;7.14,-16.32,;5.6,-16.32,;4.83,-17.64,;3.29,-17.64,;2.52,-16.3,;.98,-16.29,;3.3,-14.97,;2.53,-13.63,;4.84,-14.98,;8.29,-18.81,;6.93,-19.53,;6.87,-21.06,;8.18,-21.88,;9.54,-21.16,;10.85,-21.97,;9.59,-19.62,;10.95,-18.89,)| | ||
| Structure | 
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