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TargetE3 ubiquitin-protein ligase Mdm2
LigandBDBM50012593
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1351457 (CHEMBL3267322)
IC50 6.0±n/a nM
Citation Vaupel, A; Bold, G; De Pover, A; Stachyra-Valat, T; Hergovich-Lisztwan, J; Kallen, J; Masuya, K; Furet, P Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction. Bioorg Med Chem Lett24:2110-4 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
E3 ubiquitin-protein ligase Mdm2
Name:E3 ubiquitin-protein ligase Mdm2
Synonyms:Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:Oncoprotein
Mol. Mass.:55196.54
Organism:Homo sapiens (Human)
Description:Q00987
Residue:491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQY
IMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGT
SVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQ
RKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDS
VSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLA
DYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVP
DCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQ
DKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQ
PIQMIVLTYFP
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  Blast E-value cutoff:
BDBM50012593
n/a
NameBDBM50012593
Synonyms:CHEMBL3260820
TypeSmall organic molecule
Emp. Form.C31H26Cl2F2N6O2
Mol. Mass.623.48
SMILESNc1nnc(o1)-c1nc(C2CCCCC2)n(c1-c1ccc(F)c(Cl)c1)-c1c(CC(=O)Nc2ccccc2)ccc(Cl)c1F |(48.79,-24.38,;48.74,-25.92,;47.46,-26.78,;47.89,-28.26,;49.43,-28.31,;49.96,-26.86,;50.3,-29.59,;51.84,-29.64,;52.26,-31.12,;53.71,-31.65,;53.97,-33.17,;55.42,-33.7,;56.6,-32.71,;56.33,-31.19,;54.88,-30.66,;50.99,-31.98,;49.77,-31.03,;48.24,-31.03,;47.47,-32.35,;45.93,-32.35,;45.16,-31.01,;43.62,-31,;45.94,-29.68,;45.17,-28.34,;47.48,-29.69,;50.93,-33.51,;49.57,-34.23,;48.26,-33.42,;46.9,-34.13,;45.6,-33.32,;46.84,-35.67,;45.48,-36.39,;44.18,-35.57,;42.82,-36.29,;42.77,-37.83,;44.08,-38.65,;45.43,-37.93,;49.51,-35.77,;50.82,-36.59,;52.18,-35.86,;53.49,-36.68,;52.23,-34.33,;53.59,-33.6,)|
Structure
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