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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | E3 ubiquitin-protein ligase Mdm2 | ||
| Ligand | BDBM50012596 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_1351457 (CHEMBL3267322) | ||
| IC50 | 11±n/a nM | ||
| Citation |  Vaupel, A; Bold, G; De Pover, A; Stachyra-Valat, T; Hergovich-Lisztwan, J; Kallen, J; Masuya, K; Furet, P Tetra-substituted imidazoles as a new class of inhibitors of the p53-MDM2 interaction. Bioorg Med Chem Lett24:2110-4 (2014) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| E3 ubiquitin-protein ligase Mdm2 | |||
| Name: | E3 ubiquitin-protein ligase Mdm2 | ||
| Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein | ||
| Type: | Oncoprotein | ||
| Mol. Mass.: | 55196.54 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q00987 | ||
| Residue: | 491 | ||
| Sequence: |
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| BDBM50012596 | |||
| n/a | |||
| Name | BDBM50012596 | ||
| Synonyms: | CHEMBL3260810 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H16Cl2N2O2 | ||
| Mol. Mass. | 423.291 | ||
| SMILES | Cc1ccc(Cl)cc1-n1c(nc(C(O)=O)c1-c1cccc(Cl)c1)-c1ccccc1 |(21.82,-8.31,;23.13,-9.13,;23.07,-10.66,;24.38,-11.48,;25.74,-10.75,;27.05,-11.57,;25.79,-9.22,;24.49,-8.41,;24.55,-6.87,;25.82,-6.01,;25.4,-4.53,;23.86,-4.48,;22.99,-3.2,;23.67,-1.81,;21.46,-3.31,;23.33,-5.92,;21.8,-5.92,;21.03,-7.24,;19.49,-7.24,;18.72,-5.9,;19.5,-4.57,;18.73,-3.23,;21.04,-4.58,;27.27,-6.54,;27.53,-8.06,;28.98,-8.59,;30.16,-7.6,;29.89,-6.08,;28.44,-5.56,)| | ||
| Structure | 
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