| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 3A5 |
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| Ligand | BDBM50012905 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1351970 (CHEMBL3266607) |
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| IC50 | >50000±n/a nM |
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| Citation |  Kelly, MJ; Pietranico-Cole, S; Larigan, JD; Haynes, NE; Reynolds, CH; Scott, N; Vermeulen, J; Dvorozniak, M; Conde-Knape, K; Huang, KS; So, SS; Thakkar, K; Qian, Y; Banner, B; Mennona, F; Danzi, S; Klein, I; Taub, R; Tilley, J Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptorß agonist in clinical trials for the treatment of dyslipidemia. J Med Chem57:3912-23 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 3A5 |
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| Name: | Cytochrome P450 3A5 |
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| Synonyms: | CP3A5_HUMAN | CYP3A5 | Cytochrome P450 3A5 | Cytochrome P450 3A5 (CYP3A5) |
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| Type: | Protein |
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| Mol. Mass.: | 57118.00 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P20815 |
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| Residue: | 502 |
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| Sequence: | MDLIPNLAVETWLLLAVSLVLLYLYGTRTHGLFKRLGIPGPTPLPLLGNVLSYRQGLWKF
DTECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNRRSLGPVGFMKSAISL
AEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYGDVLVRNLRREAEKGKPVTLKDIFGAYS
MDVITGTSFGVNIDSLNNPQDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVFEALNVSL
FPKDTINFLSKSVNRMKKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELAAQSI
IFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEIDAVLPNKAPPTYDAVVQMEYLDMVV
NETLRLFPVAIRLERTCKKDVEINGVFIPKGSMVVIPTYALHHDPKYWTEPEEFRPERFS
KKKDSIDPYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLDTQG
LLQPEKPIVLKVDSRDGTLSGE
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| BDBM50012905 |
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| n/a |
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| Name | BDBM50012905 |
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| Synonyms: | CHEMBL3261331 | USRE46024, 8 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12Cl2N6O4 |
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| Mol. Mass. | 435.221 |
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| SMILES | CC(C)c1cc(Oc2c(Cl)cc(cc2Cl)-n2nc(C#N)c(=O)[nH]c2=O)n[nH]c1=O |
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| Structure | 
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