| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase ZAP-70 |
|---|
| Ligand | BDBM50013162 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1348046 (CHEMBL3268710) |
|---|
| IC50 | 33±n/a nM |
|---|
| Citation |  Thoma, G; Blanz, J; Bühlmayer, P; Drückes, P; Kittelmann, M; Smith, AB; van Eis, M; Vangrevelinghe, E; Zerwes, HG; Che, JJ; He, X; Jin, Y; Lee, CC; Michellys, PY; Uno, T; Liu, H Syk inhibitors with high potency in presence of blood. Bioorg Med Chem Lett24:2278-82 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase ZAP-70 |
|---|
| Name: | Tyrosine-protein kinase ZAP-70 |
|---|
| Synonyms: | 70 kDa zeta-associated protein | SRK | Syk-related tyrosine kinase | Tyrosine Kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 | Tyrosine-protein kinase ZAP-70 (Syk) | Tyrosine-protein kinase ZAP-70 (ZAP70) | Tyrosine-protein kinase ZAP70 | ZAP70 | ZAP70_HUMAN | Zeta-chain (TCR) associated protein kinase 70kDa |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 69881.61 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ZAP-70 SH2 domain was expressed and purified from E. coli using O-phospho-L-tyrosine-agarose column. |
|---|
| Residue: | 619 |
|---|
| Sequence: | MPDPAAHLPFFYGSISRAEAEEHLKLAGMADGLFLLRQCLRSLGGYVLSLVHDVRFHHFP
IERQLNGTYAIAGGKAHCGPAELCEFYSRDPDGLPCNLRKPCNRPSGLEPQPGVFDCLRD
AMVRDYVRQTWKLEGEALEQAIISQAPQVEKLIATTAHERMPWYHSSLTREEAERKLYSG
AQTDGKFLLRPRKEQGTYALSLIYGKTVYHYLISQDKAGKYCIPEGTKFDTLWQLVEYLK
LKADGLIYCLKEACPNSSASNASGAAAPTLPAHPSTLTHPQRRIDTLNSDGYTPEPARIT
SPDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRDNLLIADIELGCGNFGSVRQGVYRMR
KKQIDVAIKVLKQGTEKADTEEMMREAQIMHQLDNPYIVRLIGVCQAEALMLVMEMAGGG
PLHKFLVGKREEIPVSNVAELLHQVSMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDF
GLSKALGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEALSYGQKPY
KKMKGPEVMAFIEQGKRMECPPECPPELYALMSDCWIYKWEDRPDFLTVEQRMRACYYSL
ASKVEGPPGSTQKAEAACA
|
|
|
|---|
| BDBM50013162 |
|---|
| n/a |
|---|
| Name | BDBM50013162 |
|---|
| Synonyms: | CHEMBL3262357 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H25N7O |
|---|
| Mol. Mass. | 403.4802 |
|---|
| SMILES | Cc1c[nH]c2c(Nc3nc(N[C@@H]4CCCC[C@@H]4N)cc4nc[nH]c(=O)c34)cccc12 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
