| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Vitamin D3 receptor |
|---|
| Ligand | BDBM50013642 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1349194 (CHEMBL3267968) |
|---|
| IC50 | 1.6±n/a nM |
|---|
| Citation |  Anami, Y; Itoh, T; Egawa, D; Yoshimoto, N; Yamamoto, K A mixed population of antagonist and agonist binding conformers in a single crystal explains partial agonism against vitamin D receptor: active vitamin D analogues with 22R-alkyl group. J Med Chem57:4351-67 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Vitamin D3 receptor |
|---|
| Name: | Vitamin D3 receptor |
|---|
| Synonyms: | 1,25-dihydroxyvitamin D3 receptor | NR1I1 | Nuclear receptor subfamily 1 group I member 1 | Retinoic acid receptor RXR-alpha/Vitamin D3 receptor | VDR | VDR_HUMAN |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 48288.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P11473 |
|---|
| Residue: | 427 |
|---|
| Sequence: | MEAMAASTSLPDPGDFDRNVPRICGVCGDRATGFHFNAMTCEGCKGFFRRSMKRKALFTC
PFNGDCRITKDNRRHCQACRLKRCVDIGMMKEFILTDEEVQRKREMILKRKEEEALKDSL
RPKLSEEQQRIIAILLDAHHKTYDPTYSDFCQFRPPVRVNDGGGSHPSRPNSRHTPSFSG
DSSSSCSDHCITSSDMMDSSSFSNLDLSEEDSDDPSVTLELSQLSMLPHLADLVSYSIQK
VIGFAKMIPGFRDLTSEDQIVLLKSSAIEVIMLRSNESFTMDDMSWTCGNQDYKYRVSDV
TKAGHSLELIEPLIKFQVGLKKLNLHEEEHVLLMAICIVSPDRPGVQDAALIEAIQDRLS
NTLQTYIRCRHPPPGSHLLYAKMIQKLADLRSLNEEHSKQYRCLSFQPECSMKLTPLVLE
VFGNEIS
|
|
|
|---|
| BDBM50013642 |
|---|
| n/a |
|---|
| Name | BDBM50013642 |
|---|
| Synonyms: | CHEMBL3264169 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H50O3 |
|---|
| Mol. Mass. | 458.7162 |
|---|
| SMILES | [H][C@@]1([#6]-[#6][C@@]2([H])\[#6](-[#6]-[#6]-[#6][C@]12[#6])=[#6]\[#6]=[#6]-1/[#6]-[#6@@H](-[#8])-[#6](=[#6])-[#6@H](-[#8])-[#6]-1)[#6@H](-[#6])-[#6@H](-[#6]-[#6])-[#6]C([#8])([#6]-[#6])[#6]-[#6] |r| |
|---|
| Structure | 
|
|---|
Search and Browse
