| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Histamine H3 receptor |
|---|
| Ligand | BDBM50278350 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1349366 (CHEMBL3269589) |
|---|
| Ki | 0.093325±n/a nM |
|---|
| Citation |  Wingen, K; Schwed, JS; Isensee, K; Weizel, L; Zivkovic, A; Odadzic, D; Odazic, D; Stark, H Benzylpiperidine variations on histamine H3 receptor ligands for improved drug-likeness. Bioorg Med Chem Lett24:2236-9 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Histamine H3 receptor |
|---|
| Name: | Histamine H3 receptor |
|---|
| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 48691.47 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
|---|
| Residue: | 445 |
|---|
| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
|
|
|
|---|
| BDBM50278350 |
|---|
| n/a |
|---|
| Name | BDBM50278350 |
|---|
| Synonyms: | 4-fluoro-1-(4-(3-(piperidin-1-yl)propoxy)benzyl)piperidine | CHEMBL2203701 | CHEMBL513193 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H31FN2O |
|---|
| Mol. Mass. | 334.4713 |
|---|
| SMILES | FC1CCN(Cc2ccc(OCCCN3CCCCC3)cc2)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
