| Reaction Details |
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 | Report a problem with these data |
| Target | Bcl-2-like protein 1 |
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| Ligand | BDBM50013867 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1349706 (CHEMBL3266890) |
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| Ki | 10580±n/a nM |
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| Citation |  Abulwerdi, FA; Liao, C; Mady, AS; Gavin, J; Shen, C; Cierpicki, T; Stuckey, JA; Showalter, HD; Nikolovska-Coleska, Z 3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. J Med Chem57:4111-33 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bcl-2-like protein 1 |
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| Name: | Bcl-2-like protein 1 |
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| Synonyms: | Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD) |
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| Type: | Mitochondrion membrane; Single-pass membrane protein |
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| Mol. Mass.: | 26039.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 233 |
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| Sequence: | MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLA
DSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAY
QSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEP
WIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
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| BDBM50013867 |
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| n/a |
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| Name | BDBM50013867 |
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| Synonyms: | CHEMBL3265299 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H19NO6S2 |
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| Mol. Mass. | 481.541 |
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| SMILES | OC(=O)CSc1cc(NS(=O)(=O)c2ccc(Oc3ccccc3)cc2)c2ccccc2c1O |
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| Structure | 
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