| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 8 |
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| Ligand | BDBM50015233 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1349601 (CHEMBL3266025) |
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| IC50 | 1390±n/a nM |
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| Citation |  Lee, HY; Tsai, AC; Chen, MC; Shen, PJ; Cheng, YC; Kuo, CC; Pan, SL; Liu, YM; Liu, JF; Yeh, TK; Wang, JC; Chang, CY; Chang, JY; Liou, JP Azaindolylsulfonamides, with a more selective inhibitory effect on histone deacetylase 6 activity, exhibit antitumor activity in colorectal cancer HCT116 cells. J Med Chem57:4009-22 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 8 |
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| Name: | Histone deacetylase 8 |
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| Synonyms: | HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8 |
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| Type: | Enzyme |
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| Mol. Mass.: | 41749.60 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9BY41 |
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| Residue: | 377 |
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| Sequence: | MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPK
VASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATI
TAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLH
HGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKY
YQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLI
LGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPH
RIQQILNYIKGNLKHVV
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| BDBM50015233 |
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| n/a |
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| Name | BDBM50015233 |
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| Synonyms: | CHEMBL3262727 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13N3O4S |
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| Mol. Mass. | 343.357 |
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| SMILES | ONC(=O)\C=C\c1cccc(c1)S(=O)(=O)n1ccc2cccnc12 |
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| Structure | 
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