| Reaction Details |
|---|
 | Report a problem with these data |
| Target | RuvB-like 1 |
|---|
| Ligand | BDBM50015300 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1349809 (CHEMBL3268010) |
|---|
| IC50 | 18000±n/a nM |
|---|
| Citation |  Elkaim, J; Lamblin, M; Laguerre, M; Rosenbaum, J; Lestienne, P; Eloy, L; Cresteil, T; Felpin, FX; Dessolin, J Design, synthesis and biological evaluation of Pontin ATPase inhibitors through a molecular docking approach. Bioorg Med Chem Lett24:2512-6 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| RuvB-like 1 |
|---|
| Name: | RuvB-like 1 |
|---|
| Synonyms: | 49 kDa TATA box-binding protein-interacting protein | 49 kDa TBP-interacting protein | 54 kDa erythrocyte cytosolic protein | ECP-54 | INO80 complex subunit H | INO80H | NMP 238 | NMP238 | Nuclear matrix protein 238 | Pontin 52 | RUVB1_HUMAN | RUVBL1 | TAP54-alpha | TIP49 | TIP49A | TIP60-associated protein 54-alpha |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 50226.43 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_108308 |
|---|
| Residue: | 456 |
|---|
| Sequence: | MKIEEVKSTTKTQRIASHSHVKGLGLDESGLAKQAASGLVGQENAREACGVIVELIKSKK
MAGRAVLLAGPPGTGKTALALAIAQELGSKVPFCPMVGSEVYSTEIKKTEVLMENFRRAI
GLRIKETKEVYEGEVTELTPCETENPMGGYGKTISHVIIGLKTAKGTKQLKLDPSIFESL
QKERVEAGDVIYIEANSGAVKRQGRCDTYATEFDLEAEEYVPLPKGDVHKKKEIIQDVTL
HDLDVANARPQGGQDILSMMGQLMKPKKTEITDKLRGEINKVVNKYIDQGIAELVPGVLF
VDEVHMLDIECFTYLHRALESSIAPIVIFASNRGNCVIRGTEDITSPHGIPLDLLDRVMI
IRTMLYTPQEMKQIIKIRAQTEGINISEEALNHLGEIGTKTTLRYSVQLLTPANLLAKIN
GKDSIEKEHVEEISELFYDAKSSAKILADQQDKYMK
|
|
|
|---|
| BDBM50015300 |
|---|
| n/a |
|---|
| Name | BDBM50015300 |
|---|
| Synonyms: | CHEMBL3263108 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H22N4O3 |
|---|
| Mol. Mass. | 438.4779 |
|---|
| SMILES | N[C@@H](Cc1c[nH]c2ccccc12)C(=O)Nc1ccc(cc1)-c1c(O)c2ccccc2[nH]c1=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
