Reaction Details |
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Target | Legumain |
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Ligand | BDBM50015353 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1347909 (CHEMBL3267446) |
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IC50 | 9.0±n/a nM |
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Citation | Higgins, C; Bouazzaoui, S; Gaddale, K; D'Costa, Z; Templeman, A; O'Rourke, M; Young, A; Scott, C; Harrison, T; Mullan, P; Williams, R P3 SAR exploration of biphenyl carbamate based Legumain inhibitors. Bioorg Med Chem Lett24:2521-4 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Legumain |
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Name: | Legumain |
Synonyms: | 3.4.22.34 | Asparaginyl endopeptidase | LGMN | LGMN_HUMAN | PRSC1 | Protease, cysteine 1 |
Type: | n/a |
Mol. Mass.: | 49411.12 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 433 |
Sequence: | MVWKVAVFLSVALGIGAVPIDDPEDGGKHWVVIVAGSNGWYNYRHQADACHAYQIIHRNG
IPDEQIVVMMYDDIAYSEDNPTPGIVINRPNGTDVYQGVPKDYTGEDVTPQNFLAVLRGD
AEAVKGIGSGKVLKSGPQDHVFIYFTDHGSTGILVFPNEDLHVKDLNETIHYMYKHKMYR
KMVFYIEACESGSMMNHLPDNINVYATTAANPRESSYACYYDEKRSTYLGDWYSVNWMED
SDVEDLTKETLHKQYHLVKSHTNTSHVMQYGNKTISTMKVMQFQGMKRKASSPVPLPPVT
HLDLTPSPDVPLTIMKRKLMNTNDLEESRQLTEEIQRHLDARHLIEKSVRKIVSLLAASE
AEVEQLLSERAPLTGHSCYPEALLHFRTHCFNWHSPTYEYALRHLYVLVNLCEKPYPLHR
IKLSMDHVCLGHY
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BDBM50015353 |
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n/a |
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Name | BDBM50015353 |
Synonyms: | CHEMBL3264583 |
Type | Small organic molecule |
Emp. Form. | C23H23ClN4O4 |
Mol. Mass. | 454.906 |
SMILES | NC(=O)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)OCc1ccc(cc1)-c1cccc(Cl)c1)C#N |r| |
Structure |
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