| Reaction Details |
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 | Report a problem with these data |
| Target | Bone morphogenetic protein receptor type-1A |
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| Ligand | BDBM50015639 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1349304 (CHEMBL3269162) |
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| IC50 | >10000±n/a nM |
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| Citation |  Jin, CH; Krishnaiah, M; Sreenu, D; Subrahmanyam, VB; Rao, KS; Lee, HJ; Park, SJ; Park, HJ; Lee, K; Sheen, YY; Kim, DK Discovery of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2-yl)methyl)-2-fluoroaniline (EW-7197): a highly potent, selective, and orally bioavailable inhibitor of TGF-ß type I receptor kinase as cancer immunotherapeutic/antifibrotic agent. J Med Chem57:4213-38 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Bone morphogenetic protein receptor type-1A |
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| Name: | Bone morphogenetic protein receptor type-1A |
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| Synonyms: | ACVRLK3 | ALK3 | Activin receptor-like kinase 3 (ALK-3) | BMPR1A | BMR1A_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 60204.46 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P36894 |
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| Residue: | 532 |
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| Sequence: | MPQLYIYIRLLGAYLFIISRVQGQNLDSMLHGTGMKSDSDQKKSENGVTLAPEDTLPFLK
CYCSGHCPDDAINNTCITNGHCFAIIEEDDQGETTLASGCMKYEGSDFQCKDSPKAQLRR
TIECCRTNLCNQYLQPTLPPVVIGPFFDGSIRWLVLLISMAVCIIAMIIFSSCFCYKHYC
KSISSRRRYNRDLEQDEAFIPVGESLKDLIDQSQSSGSGSGLPLLVQRTIAKQIQMVRQV
GKGRYGEVWMGKWRGEKVAVKVFFTTEEASWFRETEIYQTVLMRHENILGFIAADIKGTG
SWTQLYLITDYHENGSLYDFLKCATLDTRALLKLAYSAACGLCHLHTEIYGTQGKPAIAH
RDLKSKNILIKKNGSCCIADLGLAVKFNSDTNEVDVPLNTRVGTKRYMAPEVLDESLNKN
HFQPYIMADIYSFGLIIWEMARRCITGGIVEEYQLPYYNMVPSDPSYEDMREVVCVKRLR
PIVSNRWNSDECLRAVLKLMSECWAHNPASRLTALRIKKTLAKMVESQDVKI
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| BDBM50015639 |
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| n/a |
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| Name | BDBM50015639 |
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| Synonyms: | CHEMBL3260567 | USRE47141, Example 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H18FN7 |
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| Mol. Mass. | 399.4236 |
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| SMILES | Cc1cccc(n1)-c1[nH]c(CNc2ccccc2F)nc1-c1ccc2ncnn2c1 |
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| Structure | 
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