| Reaction Details |
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 | Report a problem with these data |
| Target | Sigma non-opioid intracellular receptor 1 |
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| Ligand | BDBM50035105 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1348487 (CHEMBL3266802) |
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| Ki | 17±n/a nM |
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| Citation |  Bai, S; Li, S; Xu, J; Peng, X; Sai, K; Chu, W; Tu, Z; Zeng, C; Mach, RH Synthesis and structure-activity relationship studies of conformationally flexible tetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues ass2 receptor ligands. J Med Chem57:4239-51 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Sigma non-opioid intracellular receptor 1 |
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| Name: | Sigma non-opioid intracellular receptor 1 |
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| Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 25124.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99720 |
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| Residue: | 223 |
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| Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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| BDBM50035105 |
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| n/a |
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| Name | BDBM50035105 |
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| Synonyms: | 1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro[1,3-dihydroisobenzofuran-1,4'-(hexahydropyridine)] | 1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro[1,3-dihydroisobenzofuran-1,4'-(hexahydropyridine)](Lu 28-179) | CHEMBL61479 | Lu 28-179 | Siramesine |
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| Type | Small organic molecule |
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| Emp. Form. | C30H31FN2O |
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| Mol. Mass. | 454.5783 |
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| SMILES | Fc1ccc(cc1)-n1cc(CCCCN2CCC3(CC2)OCc2ccccc32)c2ccccc12 |
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| Structure | 
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