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TargetDihydrofolate reductase
LigandBDBM50016800
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1357878 (CHEMBL3285765)
IC50 869±n/a nM
Citation Chaykovsky, MHirst, MLazarus, HMartinelli, JE Methotrexate analogues. 9. Synthesis and biological properties of some 8-alkyl-7,8-dihydro analogues. J Med Chem20:1323-7 (1977) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:DYR_LACCA | dhfR | folA
Type:PROTEIN
Mol. Mass.:18437.08
Organism:Lactobacillus casei
Description:ChEMBL_1357878
Residue:163
Sequence:
MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN
VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA
GSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
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  Blast E-value cutoff:
BDBM50016800
n/a
NameBDBM50016800
Synonyms:CHEMBL3273851
TypeSmall organic molecule
Emp. Form.C27H36N8O5
Mol. Mass.552.6253
SMILESCN(CC1=Nc2c(N)nc(N)nc2N(CC2CCCCC2)C1)c1ccc(cc1)C(=O)N[C@@H](CCC(O)=O)C(O)=O |r,t:3|
Structure
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