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TargetDihydrofolate reductase
LigandBDBM50016802
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1357878
IC50 900±n/a nM
Citation Chaykovsky MHirst MLazarus HMartinelli JE Methotrexate analogues. 9. Synthesis and biological properties of some 8-alkyl-7,8-dihydro analogues. J Med Chem 20:1323-7 (1977) [PubMed]
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Dihydrofolate reductase
Name:Dihydrofolate reductase
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:18437.08
Organism:Lactobacillus casei
Description:ChEMBL_1357878
Residue:163
Sequence:
MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTN
VVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLA
GSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
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BDBM50016802
n/a
NameBDBM50016802
Synonyms:CHEMBL3273848
TypeSmall organic molecule
Emp. Form.C22H28N8O5
Mol. Mass.484.5083
SMILESCCN1CC(CN(C)c2ccc(cc2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)=Nc2c(N)nc(N)nc12 |r,c:26|
Structure
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