Reaction Details |
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Target | Histone deacetylase 1 |
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Ligand | BDBM50016948 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1362738 (CHEMBL3294937) |
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IC50 | 580±n/a nM |
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Citation | Methot, JL; Hoffman, DM; Witter, DJ; Stanton, MG; Harrington, P; Hamblett, C; Siliphaivanh, P; Wilson, K; Hubbs, J; Heidebrecht, R; Kral, AM; Ozerova, N; Fleming, JC; Wang, H; Szewczak, AA; Middleton, RE; Hughes, B; Cruz, JC; Haines, BB; Chenard, M; Kenific, CM; Harsch, A; Secrist, JP; Miller, TA Delayed and Prolonged Histone Hyperacetylation with a Selective HDAC1/HDAC2 Inhibitor. ACS Med Chem Lett5:340-5 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 1 |
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Name: | Histone deacetylase 1 |
Synonyms: | Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1 |
Type: | Enzyme |
Mol. Mass.: | 55090.27 |
Organism: | Homo sapiens (Human) |
Description: | Q13547 |
Residue: | 482 |
Sequence: | MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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BDBM50016948 |
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n/a |
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Name | BDBM50016948 |
Synonyms: | CHEMBL3286739 |
Type | Small organic molecule |
Emp. Form. | C19H21N5O3 |
Mol. Mass. | 367.4017 |
SMILES | Nc1ccccc1NC(=O)c1ccc(nc1)N1CCC2(CNC(=O)O2)CC1 |
Structure |
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