| Reaction Details |
|---|
 | Report a problem with these data |
| Target | 11-beta-hydroxysteroid dehydrogenase 1 |
|---|
| Ligand | BDBM50016982 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1364746 (CHEMBL3294007) |
|---|
| IC50 | 1.000000±n/a nM |
|---|
| Citation |  Scott, JS; Goldberg, FW; Turnbull, AV Medicinal chemistry of inhibitors of 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1). J Med Chem57:4466-86 (2014) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| 11-beta-hydroxysteroid dehydrogenase 1 |
|---|
| Name: | 11-beta-hydroxysteroid dehydrogenase 1 |
|---|
| Synonyms: | 11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 32409.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P28845 |
|---|
| Residue: | 292 |
|---|
| Sequence: | MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAH
VVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNH
ITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMV
AAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEE
CALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
|
|
|
|---|
| BDBM50016982 |
|---|
| n/a |
|---|
| Name | BDBM50016982 |
|---|
| Synonyms: | CHEMBL3287027 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H27Cl3N4O4S |
|---|
| Mol. Mass. | 549.898 |
|---|
| SMILES | NC(=O)[C@@]12CC3CC(C[C@](C3)(C1)NC(=O)CN1CCCN(c3c(Cl)cc(Cl)cc3Cl)S1(=O)=O)C2 |r,TLB:33:3:8.7.6:10,THB:33:7:10:11.3.4,4:3:8:6.5.10,4:5:8:11.33.3,1:3:8:6.5.10,1:3:8.7.6:10| |
|---|
| Structure | 
|
|---|
Search and Browse
