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TargetP2Y purinoceptor 1
LigandBDBM50017091
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1365183 (CHEMBL3292933)
IC50 0.370000±n/a nM
Citation Jeon, YTYang, WQiao, JXLi, LRuel, RThibeault, CHiebert, SWang, TCWang, YLiu, YClark, CGWong, HSZhu, JWu, DRSun, DChen, BCMathur, AChacko, SAMalley, MChen, XQShen, HHuang, CSSchumacher, WABostwick, JSStewart, ABPrice, LAHua, JLi, DLevesque, PCSeiffert, DARehfuss, RWexler, RRLam, PY Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent. Bioorg Med Chem Lett24:1294-8 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
P2Y purinoceptor 1
Name:P2Y purinoceptor 1
Synonyms:ATP receptor | P2RY1 | P2RY1_HUMAN | P2Y purinoceptor 1 (P2Y1) | P2Y1 | Purinergic receptor | Purinergic receptor P2Y1
Type:Enzyme
Mol. Mass.:42090.25
Organism:Homo sapiens (Human)
Description:P47900
Residue:373
Sequence:
MTEVLWPAVPNGTDAAFLAGPGSSWGNSTVASTAAVSSSFKCALTKTGFQFYYLPAVYIL
VFIIGFLGNSVAIWMFVFHMKPWSGISVYMFNLALADFLYVLTLPALIFYYFNKTDWIFG
DAMCKLQRFIFHVNLYGSILFLTCISAHRYSGVVYPLKSLGRLKKKNAICISVLVWLIVV
VAISPILFYSGTGVRKNKTITCYDTTSDEYLRSYFIYSMCTTVAMFCVPLVLILGCYGLI
VRALIYKDLDNSPLRRKSIYLVIIVLTVFAVSYIPFHVMKTMNLRARLDFQTPAMCAFND
RVYATYQVTRGLASLNSCVDPILYFLAGDTFRRRLSRATRKASRRSEANLQSKSEDMTLN
ILPEFKQNGDTSL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50017091
n/a
NameBDBM50017091
Synonyms:CHEMBL3287045 | US9428504, 6
TypeSmall organic molecule
Emp. Form.C31H34F4N4O3
Mol. Mass.586.6203
SMILESCC(C)(C)CN1CCC2(CN(c3c2c(F)ccc3O)c2ccccc2NC(=O)Nc2ccc(OC(F)(F)F)cc2)CC1
Structure
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