Reaction Details | |||
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Ligand | BDBM50017301 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1362418 (CHEMBL3292526) | ||
IC50 | 0.025119±n/a nM | ||
Citation | De Savi, C; Cox, RJ; Warner, DJ; Cook, AR; Dickinson, MR; McDonough, A; Morrill, LC; Parker, B; Andrews, G; Young, SS; Gilmour, PS; Riley, R; Dearman, MS Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. J Med Chem57:4661-76 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
Type: | Protein | ||
Mol. Mass.: | 83318.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q07343 | ||
Residue: | 736 | ||
Sequence: |
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BDBM50017301 | |||
n/a | |||
Name | BDBM50017301 | ||
Synonyms: | CHEMBL3287988 | ||
Type | Small organic molecule | ||
Emp. Form. | C34H36FN5O5S | ||
Mol. Mass. | 645.744 | ||
SMILES | Cc1nc(cs1)C(=O)N[C@H]1CC[C@H](CC1)NC(=O)c1cc(F)cnc1Oc1cccc(c1)-c1ccc(O)cc1CN1CCOCC1 |r,wU:12.16,9.9,(23.21,-22.73,;21.67,-22.78,;20.81,-24.05,;19.33,-23.61,;19.28,-22.09,;20.73,-21.56,;18.11,-24.55,;18.11,-26.09,;16.78,-23.78,;15.44,-24.55,;15.44,-26.09,;14.11,-26.86,;12.77,-26.09,;12.77,-24.55,;14.11,-23.78,;11.44,-26.86,;10.11,-26.1,;10.1,-24.56,;8.77,-26.87,;7.44,-26.11,;6.11,-26.88,;4.78,-26.11,;6.11,-28.42,;7.44,-29.19,;8.78,-28.42,;10.11,-29.19,;10.12,-30.73,;8.78,-31.5,;8.78,-33.04,;10.12,-33.81,;11.46,-33.03,;11.45,-31.49,;12.79,-33.79,;12.8,-35.33,;14.13,-36.09,;15.46,-35.31,;16.8,-36.07,;15.45,-33.77,;14.11,-33.01,;14.1,-31.47,;15.43,-30.69,;16.76,-31.45,;18.09,-30.67,;18.08,-29.13,;16.73,-28.37,;15.41,-29.15,)| | ||
Structure |