Reaction Details | |||
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Ligand | BDBM50017308 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1362418 (CHEMBL3292526) | ||
IC50 | 0.015849±n/a nM | ||
Citation | De Savi, C; Cox, RJ; Warner, DJ; Cook, AR; Dickinson, MR; McDonough, A; Morrill, LC; Parker, B; Andrews, G; Young, SS; Gilmour, PS; Riley, R; Dearman, MS Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. J Med Chem57:4661-76 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
Type: | Protein | ||
Mol. Mass.: | 83318.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q07343 | ||
Residue: | 736 | ||
Sequence: |
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BDBM50017308 | |||
n/a | |||
Name | BDBM50017308 | ||
Synonyms: | CHEMBL3287995 | ||
Type | Small organic molecule | ||
Emp. Form. | C38H39FN6O5 | ||
Mol. Mass. | 678.7519 | ||
SMILES | Cc1cccc2nc(cn12)C(=O)N[C@H]1CC[C@H](CC1)NC(=O)c1cc(F)cnc1Oc1cccc(c1)-c1ccc(O)cc1CN1CCOCC1 |r,wU:13.14,16.21,(37.17,-18.1,;38.11,-19.31,;39.63,-19.1,;40.58,-20.32,;39.99,-21.74,;38.48,-21.94,;37.62,-23.22,;36.14,-22.77,;36.09,-21.25,;37.54,-20.73,;34.92,-23.72,;34.92,-25.26,;33.59,-22.95,;32.24,-23.72,;32.24,-25.26,;30.91,-26.03,;29.57,-25.26,;29.57,-23.72,;30.91,-22.95,;28.24,-26.03,;26.91,-25.27,;26.9,-23.73,;25.57,-26.04,;24.24,-25.28,;22.9,-26.05,;21.57,-25.28,;22.9,-27.59,;24.24,-28.37,;25.58,-27.59,;26.91,-28.36,;26.92,-29.91,;25.58,-30.67,;25.58,-32.21,;26.92,-32.99,;28.26,-32.2,;28.25,-30.66,;29.59,-32.96,;29.6,-34.51,;30.93,-35.27,;32.27,-34.49,;33.6,-35.25,;32.25,-32.94,;30.92,-32.18,;30.9,-30.64,;32.23,-29.86,;33.57,-30.63,;34.89,-29.86,;34.89,-28.32,;33.55,-27.56,;32.22,-28.33,)| | ||
Structure |