Reaction Details | |||
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Ligand | BDBM50017312 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1362418 (CHEMBL3292526) | ||
IC50 | 0.050119±n/a nM | ||
Citation | De Savi, C; Cox, RJ; Warner, DJ; Cook, AR; Dickinson, MR; McDonough, A; Morrill, LC; Parker, B; Andrews, G; Young, SS; Gilmour, PS; Riley, R; Dearman, MS Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. J Med Chem57:4661-76 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
Type: | Protein | ||
Mol. Mass.: | 83318.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q07343 | ||
Residue: | 736 | ||
Sequence: |
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BDBM50017312 | |||
n/a | |||
Name | BDBM50017312 | ||
Synonyms: | CHEMBL3287998 | ||
Type | Small organic molecule | ||
Emp. Form. | C35H34F2N6O4 | ||
Mol. Mass. | 640.6791 | ||
SMILES | CN(C)Cc1cc(O)ccc1-c1cccc(Oc2ncc(F)cc2C(=O)N[C@@H]2CC[C@@H](CC2)NC(=O)c2cn3cc(F)ccc3n2)c1 |r,wU:30.35,27.28,(39.15,-11.76,;37.81,-10.99,;37.8,-9.46,;36.48,-11.77,;36.5,-13.31,;37.83,-14.07,;37.85,-15.62,;39.19,-16.38,;36.51,-16.39,;35.18,-15.63,;35.17,-14.09,;33.84,-13.33,;32.5,-14.11,;31.17,-13.34,;31.16,-11.8,;32.5,-11.03,;32.5,-9.49,;31.16,-8.72,;29.82,-9.49,;28.48,-8.72,;28.48,-7.17,;27.15,-6.41,;29.82,-6.4,;31.16,-7.16,;32.49,-6.39,;32.48,-4.85,;33.82,-7.15,;35.15,-6.38,;36.5,-7.15,;37.82,-6.39,;37.82,-4.85,;36.49,-4.07,;35.15,-4.85,;39.17,-4.07,;40.5,-4.85,;40.5,-6.39,;41.72,-3.9,;41.67,-2.37,;43.12,-1.85,;43.69,-.44,;45.21,-.23,;45.78,1.21,;46.15,-1.44,;45.57,-2.86,;44.06,-3.07,;43.2,-4.34,;33.83,-11.79,)| | ||
Structure |