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TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B
LigandBDBM50017317
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1362418 (CHEMBL3292526)
IC50 0.125893±n/a nM
Citation De Savi, CCox, RJWarner, DJCook, ARDickinson, MRMcDonough, AMorrill, LCParker, BAndrews, GYoung, SSGilmour, PSRiley, RDearman, MS Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. J Med Chem57:4661-76 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Name:cAMP-specific 3',5'-cyclic phosphodiesterase 4B
Synonyms:3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B)
Type:Protein
Mol. Mass.:83318.87
Organism:Homo sapiens (Human)
Description:Q07343
Residue:736
Sequence:
MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS
ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL
HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR
NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR
SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK
KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH
NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV
LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL
AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS
SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI
SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP
SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG
ETDIDIATEDKSPVDT
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  Blast E-value cutoff:
BDBM50017317
n/a
NameBDBM50017317
Synonyms:CHEMBL3288003
TypeSmall organic molecule
Emp. Form.C35H36FN5O6
Mol. Mass.641.6886
SMILESOc1ccc(c(CN2CCOCC2)c1)-c1cccc(Oc2ncc(F)cc2C(=O)N[C@H]2CC[C@H](CC2)NC(=O)c2ncccc2O)c1 |r,wU:33.39,30.32,(32.12,-20.38,;30.78,-19.62,;29.45,-20.4,;28.11,-19.64,;28.1,-18.09,;29.43,-17.31,;29.41,-15.77,;30.74,-14.99,;32.08,-15.76,;33.4,-14.99,;33.4,-13.45,;32.06,-12.69,;30.73,-13.46,;30.76,-18.07,;26.77,-17.33,;25.43,-18.12,;24.09,-17.34,;24.09,-15.8,;25.43,-15.04,;25.43,-13.49,;24.09,-12.72,;22.75,-13.5,;21.41,-12.72,;21.41,-11.18,;20.08,-10.41,;22.75,-10.41,;24.08,-11.17,;25.42,-10.4,;25.41,-8.85,;26.75,-11.16,;28.08,-10.39,;28.08,-8.85,;29.42,-8.08,;30.76,-8.85,;30.75,-10.39,;29.43,-11.16,;32.1,-8.07,;33.43,-8.85,;33.43,-10.39,;34.76,-8.08,;36.09,-8.86,;37.42,-8.09,;37.42,-6.55,;36.08,-5.79,;34.76,-6.55,;33.42,-5.79,;26.76,-15.79,)|
Structure
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