Reaction Details | |||
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Ligand | BDBM50017317 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1362418 (CHEMBL3292526) | ||
IC50 | 0.125893±n/a nM | ||
Citation | De Savi, C; Cox, RJ; Warner, DJ; Cook, AR; Dickinson, MR; McDonough, A; Morrill, LC; Parker, B; Andrews, G; Young, SS; Gilmour, PS; Riley, R; Dearman, MS Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. J Med Chem57:4661-76 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
Type: | Protein | ||
Mol. Mass.: | 83318.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q07343 | ||
Residue: | 736 | ||
Sequence: |
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BDBM50017317 | |||
n/a | |||
Name | BDBM50017317 | ||
Synonyms: | CHEMBL3288003 | ||
Type | Small organic molecule | ||
Emp. Form. | C35H36FN5O6 | ||
Mol. Mass. | 641.6886 | ||
SMILES | Oc1ccc(c(CN2CCOCC2)c1)-c1cccc(Oc2ncc(F)cc2C(=O)N[C@H]2CC[C@H](CC2)NC(=O)c2ncccc2O)c1 |r,wU:33.39,30.32,(32.12,-20.38,;30.78,-19.62,;29.45,-20.4,;28.11,-19.64,;28.1,-18.09,;29.43,-17.31,;29.41,-15.77,;30.74,-14.99,;32.08,-15.76,;33.4,-14.99,;33.4,-13.45,;32.06,-12.69,;30.73,-13.46,;30.76,-18.07,;26.77,-17.33,;25.43,-18.12,;24.09,-17.34,;24.09,-15.8,;25.43,-15.04,;25.43,-13.49,;24.09,-12.72,;22.75,-13.5,;21.41,-12.72,;21.41,-11.18,;20.08,-10.41,;22.75,-10.41,;24.08,-11.17,;25.42,-10.4,;25.41,-8.85,;26.75,-11.16,;28.08,-10.39,;28.08,-8.85,;29.42,-8.08,;30.76,-8.85,;30.75,-10.39,;29.43,-11.16,;32.1,-8.07,;33.43,-8.85,;33.43,-10.39,;34.76,-8.08,;36.09,-8.86,;37.42,-8.09,;37.42,-6.55,;36.08,-5.79,;34.76,-6.55,;33.42,-5.79,;26.76,-15.79,)| | ||
Structure |