Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Ligand | BDBM50017325 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1362418 (CHEMBL3292526) | ||
IC50 | 0.398107±n/a nM | ||
Citation | De Savi, C; Cox, RJ; Warner, DJ; Cook, AR; Dickinson, MR; McDonough, A; Morrill, LC; Parker, B; Andrews, G; Young, SS; Gilmour, PS; Riley, R; Dearman, MS Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. J Med Chem57:4661-76 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
Type: | Protein | ||
Mol. Mass.: | 83318.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q07343 | ||
Residue: | 736 | ||
Sequence: |
| ||
BDBM50017325 | |||
n/a | |||
Name | BDBM50017325 | ||
Synonyms: | CHEMBL3288014 | ||
Type | Small organic molecule | ||
Emp. Form. | C32H34FN5O3S | ||
Mol. Mass. | 587.707 | ||
SMILES | CN(C)Cc1ccc(cc1)-c1cccc(Oc2ncc(F)cc2C(=O)N[C@@H]2CC[C@@H](CC2)NC(=O)c2csc(C)n2)c1 |r,wU:29.34,26.27,(13.15,-16.41,;14.48,-15.64,;15.81,-16.39,;14.47,-14.11,;13.14,-13.35,;11.8,-14.12,;10.47,-13.36,;10.46,-11.82,;11.79,-11.04,;13.12,-11.8,;9.13,-11.06,;7.79,-11.84,;6.46,-11.07,;6.45,-9.53,;7.79,-8.76,;7.79,-7.22,;6.45,-6.45,;5.11,-7.22,;3.77,-6.45,;3.77,-4.9,;2.44,-4.14,;5.11,-4.14,;6.45,-4.9,;7.78,-4.13,;7.77,-2.58,;9.11,-4.89,;10.44,-4.12,;11.79,-4.89,;13.11,-4.12,;13.11,-2.58,;11.78,-1.81,;10.44,-2.58,;14.46,-1.81,;15.79,-2.58,;15.79,-4.12,;17.01,-1.63,;16.96,-.11,;18.41,.42,;19.35,-.8,;20.89,-.75,;18.49,-2.08,;9.12,-9.52,)| | ||
Structure |