Reaction Details | |||
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Ligand | BDBM50017329 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1362418 (CHEMBL3292526) | ||
IC50 | 0.794328±n/a nM | ||
Citation | De Savi, C; Cox, RJ; Warner, DJ; Cook, AR; Dickinson, MR; McDonough, A; Morrill, LC; Parker, B; Andrews, G; Young, SS; Gilmour, PS; Riley, R; Dearman, MS Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. J Med Chem57:4661-76 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
Type: | Protein | ||
Mol. Mass.: | 83318.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q07343 | ||
Residue: | 736 | ||
Sequence: |
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BDBM50017329 | |||
n/a | |||
Name | BDBM50017329 | ||
Synonyms: | CHEMBL3288018 | ||
Type | Small organic molecule | ||
Emp. Form. | C36H37FN6O3 | ||
Mol. Mass. | 620.7158 | ||
SMILES | CN(C)Cc1ccc(cc1)-c1cccc(Oc2ncc(F)cc2C(=O)N[C@@H]2CC[C@@H](CC2)NC(=O)c2cn3c(C)cccc3n2)c1 |r,wU:29.34,26.27,(15.65,-19.05,;16.97,-18.28,;18.3,-19.05,;16.96,-16.75,;15.63,-15.99,;14.3,-16.76,;12.96,-16,;12.96,-14.46,;14.28,-13.68,;15.62,-14.44,;11.62,-13.7,;10.29,-14.48,;8.95,-13.71,;8.95,-12.17,;10.29,-11.41,;10.28,-9.87,;8.95,-9.09,;7.61,-9.87,;6.27,-9.09,;6.27,-7.55,;4.94,-6.78,;7.61,-6.78,;8.94,-7.54,;10.27,-6.77,;10.27,-5.23,;11.61,-7.53,;12.94,-6.76,;14.28,-7.53,;15.61,-6.77,;15.61,-5.23,;14.27,-4.45,;12.94,-5.23,;16.95,-4.45,;18.28,-5.23,;18.28,-6.77,;19.5,-4.28,;19.45,-2.76,;20.9,-2.23,;21.48,-.81,;20.54,.4,;23.01,-.6,;23.96,-1.83,;23.37,-3.26,;21.84,-3.46,;20.98,-4.72,;11.62,-12.16,)| | ||
Structure |