Reaction Details | |||
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Ligand | BDBM50017332 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1362418 (CHEMBL3292526) | ||
IC50 | 0.125893±n/a nM | ||
Citation | De Savi, C; Cox, RJ; Warner, DJ; Cook, AR; Dickinson, MR; McDonough, A; Morrill, LC; Parker, B; Andrews, G; Young, SS; Gilmour, PS; Riley, R; Dearman, MS Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. J Med Chem57:4661-76 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
Type: | Protein | ||
Mol. Mass.: | 83318.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q07343 | ||
Residue: | 736 | ||
Sequence: |
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BDBM50017332 | |||
n/a | |||
Name | BDBM50017332 | ||
Synonyms: | CHEMBL3288021 | ||
Type | Small organic molecule | ||
Emp. Form. | C37H41FN6O4 | ||
Mol. Mass. | 652.7576 | ||
SMILES | C[C@H]1CN(Cc2ccc(cc2)-c2cccc(Oc3ncc(F)cc3C(=O)N[C@H]3CC[C@H](CC3)NC(=O)c3ncccc3O)c2)C[C@@H](C)N1 |r,wU:30.35,27.28,1.0,45.50,(12.67,-41.64,;14,-40.87,;13.99,-39.34,;15.32,-38.58,;15.31,-37.04,;13.97,-36.28,;12.64,-37.05,;11.3,-36.29,;11.3,-34.75,;12.62,-33.97,;13.96,-34.73,;9.96,-33.98,;8.62,-34.77,;7.29,-34,;7.28,-32.45,;8.62,-31.69,;8.62,-30.14,;7.28,-29.37,;5.94,-30.15,;4.6,-29.37,;4.6,-27.82,;3.27,-27.06,;5.94,-27.06,;7.28,-27.82,;8.61,-27.05,;8.6,-25.5,;9.95,-27.81,;11.28,-27.04,;11.27,-25.5,;12.61,-24.72,;13.95,-25.5,;13.95,-27.04,;12.62,-27.81,;15.29,-24.72,;16.63,-25.5,;16.63,-27.04,;17.96,-24.73,;19.29,-25.51,;20.62,-24.74,;20.62,-23.21,;19.28,-22.44,;17.96,-23.21,;16.62,-22.44,;9.95,-32.45,;16.65,-39.33,;16.66,-40.87,;17.99,-41.63,;15.33,-41.64,)| | ||
Structure |