Reaction Details | |||
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Target | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Ligand | BDBM50017336 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1362418 (CHEMBL3292526) | ||
IC50 | 0.031623±n/a nM | ||
Citation | De Savi, C; Cox, RJ; Warner, DJ; Cook, AR; Dickinson, MR; McDonough, A; Morrill, LC; Parker, B; Andrews, G; Young, SS; Gilmour, PS; Riley, R; Dearman, MS Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD. J Med Chem57:4661-76 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B | |||
Name: | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | ||
Synonyms: | 3',5'-cyclic phosphodiesterase | DPDE4 | Isoform PDE4B1 | PDE32 | PDE4B | PDE4B1 | PDE4B_HUMAN | Phosphodiesterase 4B | Phosphodiesterase 4B (PDE4B) | Phosphodiesterase 4B (PDE4B1) | Phosphodiesterase Type 4 (PDE4B) | ||
Type: | Protein | ||
Mol. Mass.: | 83318.87 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q07343 | ||
Residue: | 736 | ||
Sequence: |
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BDBM50017336 | |||
n/a | |||
Name | BDBM50017336 | ||
Synonyms: | CHEMBL3288025 | ||
Type | Small organic molecule | ||
Emp. Form. | C37H44FN7O4 | ||
Mol. Mass. | 669.7882 | ||
SMILES | C[C@H]1CN(Cc2cc(O)cc(c2)-c2cccc(Oc3ncc(F)cc3C(=O)N[C@@H]3CC[C@@H](CC3)NC(=O)c3cc(C)n(C)n3)c2)C[C@@H](C)N1 |r,wU:46.51,1.0,31.36,28.29,(42.43,-41.61,;42.45,-40.08,;41.13,-39.3,;41.14,-37.77,;39.79,-37.06,;38.46,-37.83,;38.47,-39.39,;37.14,-40.16,;37.15,-41.69,;35.81,-39.4,;35.8,-37.85,;37.12,-37.07,;34.46,-37.09,;33.13,-37.88,;31.79,-37.1,;31.79,-35.56,;33.12,-34.8,;33.12,-33.25,;31.79,-32.48,;30.45,-33.26,;29.1,-32.48,;29.11,-30.93,;27.77,-30.17,;30.44,-30.17,;31.78,-30.93,;33.11,-30.16,;33.11,-28.61,;34.45,-30.92,;35.78,-30.15,;37.12,-30.92,;38.45,-30.15,;38.45,-28.61,;37.12,-27.83,;35.78,-28.61,;39.8,-27.83,;41.13,-28.61,;41.13,-30.15,;42.35,-27.66,;42.3,-26.13,;43.75,-25.61,;44.18,-24.14,;44.69,-26.83,;46.23,-26.78,;43.83,-28.11,;34.46,-35.55,;42.47,-37,;43.79,-37.79,;45.13,-37.03,;43.78,-39.32,)| | ||
Structure |