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TargetIntegrase
LigandBDBM50017350
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1363202 (CHEMBL3294150)
IC50 20±n/a nM
Citation Suchaud, VBailly, FLion, CCalmels, CAndréola, MLChrist, FDebyser, ZCotelle, P Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors. J Med Chem57:4640-60 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Integrase
Name:Integrase
Synonyms:Human immunodeficiency virus type 1 integrase
Type:PROTEIN
Mol. Mass.:32231.48
Organism:Human immunodeficiency virus 1
Description:ChEMBL_90865
Residue:288
Sequence:
FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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BDBM50017350
n/a
NameBDBM50017350
Synonyms:CHEMBL3288281
TypeSmall organic molecule
Emp. Form.C18H12F4N2O4
Mol. Mass.396.2925
SMILESON1C(=O)C(C(=O)NCc2ccc(F)cc2)c2ccc(cc2C1=O)C(F)(F)F
Structure
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