| Reaction Details |
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 | Report a problem with these data |
| Target | Integrase |
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| Ligand | BDBM50017359 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1363202 (CHEMBL3294150) |
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| IC50 | 10.0±n/a nM |
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| Citation |  Suchaud, V; Bailly, F; Lion, C; Calmels, C; Andréola, ML; Christ, F; Debyser, Z; Cotelle, P Investigation of a novel series of 2-hydroxyisoquinoline-1,3(2H,4H)-diones as human immunodeficiency virus type 1 integrase inhibitors. J Med Chem57:4640-60 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Integrase |
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| Name: | Integrase |
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| Synonyms: | Human immunodeficiency virus type 1 integrase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 32231.48 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_90865 |
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| Residue: | 288 |
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| Sequence: | FLDGIDKAQDEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGI
WQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTIHTDNGSN
FTSTTVKAACWWAGIKQEFGIPYNPQSQGVVESMNKELKKIIGQVRDQAEHLKTAVQMAV
FIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPLWKGPAK
LLWKGEGAVVIQDNSDIKVVPRRKVKIIRDYGKQMAGDDCVASRQDED
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| BDBM50017359 |
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| n/a |
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| Name | BDBM50017359 |
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| Synonyms: | CHEMBL3288265 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H13N3O6 |
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| Mol. Mass. | 355.3016 |
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| SMILES | Oc1c(C(=O)NCc2ccccc2)c2ccc(cc2c(=O)n1O)[N+]([O-])=O |
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| Structure | 
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