Reaction Details |
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Target | RAS guanyl-releasing protein 1 |
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Ligand | BDBM50017891 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1364410 (CHEMBL3294522) |
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Ki | 0.870000±n/a nM |
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Citation | Garcia, LC; Donadío, LG; Mann, E; Kolusheva, S; Kedei, N; Lewin, NE; Hill, CS; Kelsey, JS; Yang, J; Esch, TE; Santos, M; Peach, ML; Kelley, JA; Blumberg, PM; Jelinek, R; Marquez, VE; Comin, MJ Synthesis, biological, and biophysical studies of DAG-indololactones designed as selective activators of RasGRP. Bioorg Med Chem22:3123-40 (2014) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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RAS guanyl-releasing protein 1 |
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Name: | RAS guanyl-releasing protein 1 |
Synonyms: | CalDAG-GEFII | Calcium and DAG-regulated guanine nucleotide exchange factor II | GRP1_HUMAN | RASGRP | RASGRP1 | Ras guanyl-releasing protein |
Type: | PROTEIN |
Mol. Mass.: | 90418.98 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_102739 |
Residue: | 797 |
Sequence: | MGTLGKAREAPRKPSHGCRAASKARLEAKPANSPFPSHPSLAHITQFRMMVSLGHLAKGA
SLDDLIDSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLYKDALAKNSPG
LCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQINARDWS
RKLTQRIKSNTSKKRKVSLLFDHLEPEELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKE
NPTMERSIALCNGISQWVQLMVLSRPTPQLRAEVFIKFIQVAQKLHQLQNFNTLMAVIGG
LCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRNYDNYRRAYGECTDFKIPILGVHLK
DLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAPPLEANKDLVHLLTLSLDLY
YTEDEIYELSYAREPRNHRAPPLTPSKPPVVVDWASGVSPKPDPKTISKHVQRMVDSVFK
NYDHDQDGYISQEEFEKIAASFPFSFCVMDKDREGLISRDEITAYFMRASSIYSKLGLGF
PHNFQETTYLKPTFCDNCAGFLWGVIKQGYRCKDCGMNCHKQCKDLVVFECKKRAKNPVA
PTENNTSVGPVSNLCSLGAKDLLHAPEEGPFTFPNGEAVEHGEESKDRTIMLMGVSSQKI
SLRLKRAVAHKATQTESQPWIGSEGPSGPFVLSSPRKTAQDTLYVLPSPTSPCPSPVLVR
KRAFVKWENKDSLIKSKEELRHLRLPTYQELEQEINTLKADNDALKIQLKYAQKKIESLQ
LEKSNHVLAQMEQGDCS
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BDBM50017891 |
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n/a |
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Name | BDBM50017891 |
Synonyms: | CHEMBL3289013 |
Type | Small organic molecule |
Emp. Form. | C24H31NO5 |
Mol. Mass. | 413.5066 |
SMILES | CCCC(CCC)C(=O)OCC1(CO)C\C(=C/c2ccc3ccn(C)c3c2)C(=O)O1 |
Structure |
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